Zinc, calcium and magnesium ion coordination of vinblastine and vindoline

M. Véber, P. Sipos, K. Burger

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Zinc ions were shown by polarography to coordinate strongly to vinblastine and to vindoline. A calcium or magnesium ion excess liberated these alkaloids from their zinc complexes. The calcium ion coordination of vinblastine was investigated with a calcium ion-selective electrode. The complex formation processes proved to be pH-independent in the pH range 3.5-5.0. The experimental results, together with others on analogous vincristine-containing systems, indicate that the metal ions are coordinated to non-protonating oxygen donor atoms on the vindoline moiety of vincristine or vinblastine.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalInorganica Chimica Acta
Volume156
Issue number1
DOIs
Publication statusPublished - Feb 1 1989

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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