Zinc as a possible mediator of signal transduction in T lymphocytes.

P. Csermely, J. Somogyi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Our recent findings indicate that phorbol esters, the specific activators of protein kinase C induce the translocation of heavy metals (mostly: zinc) from the nucleus and mitochondria to the cytosol and microsomes of T lymphocytes. Phorbol ester treatment impairs the action of Ca-ionophores, this effect is mediated by intracellular heavy metal ions (most probably: by zinc). Zinc activates cytosolic protein kinase C, increases its affinity towards phorbol esters and contributes to its binding to plasma membranes. These results suggest that zinc may play a role in the "cross-talk" of second messengers and hence in signal transduction in T lymphocytes.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalActa physiologica Hungarica
Volume74
Issue number2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Physiology (medical)

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