Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology

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Abstract

OBJECTIVE: Our experiments were designed to investigate the effects of zerumbone pretreatment on cholecystokinin octapeptide (CCK-8)-induced acute pancreatitis in rats. METHODS: Male Wistar rats weighing 240 to 280 g were divided into a control group, a group treated with CCK-8, a group receiving 20 mg/kg zerumbone before CCK-8 administration, and a group treated with zerumbone only. RESULTS: The serum amylase and lipase activities and the pancreatic weight-body weight ratio were significantly reduced by zerumbone pretreatment, but the drug failed to influence the histological parameters of pancreatitis. The anti-inflammatory effects of the drug were manifested in decreases in the cytosolic interleukin 6 and tumor necrosis factor α concentrations and an elevation in the I-κB concentration, whereas the antioxidant ability of zerumbone was demonstrated by reductions in inducible nitric oxide synthase, Mn- and Cu/Zn-superoxide dismutase activities in the zerumbone-treated rats. CONCLUSION: Zerumbone ameliorated the changes of several parameters of acute pancreatitis probably by interfering with I-κB degradation, but in the applied dose, it failed to influence the histology of the disease.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalPancreas.
Volume35
Issue number3
DOIs
Publication statusPublished - Oct 2007

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Sincalide
Pancreatitis
Histology
Nitric Oxide Synthase Type II
Amylases
zerumbone
Lipase
Pharmaceutical Preparations
Wistar Rats
Interleukin-6
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Antioxidants
Body Weight
Weights and Measures
Control Groups
Serum

Keywords

  • Pancreatitis
  • Rat
  • Zerumbone

ASJC Scopus subject areas

  • Gastroenterology
  • Endocrinology

Cite this

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title = "Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology",
abstract = "OBJECTIVE: Our experiments were designed to investigate the effects of zerumbone pretreatment on cholecystokinin octapeptide (CCK-8)-induced acute pancreatitis in rats. METHODS: Male Wistar rats weighing 240 to 280 g were divided into a control group, a group treated with CCK-8, a group receiving 20 mg/kg zerumbone before CCK-8 administration, and a group treated with zerumbone only. RESULTS: The serum amylase and lipase activities and the pancreatic weight-body weight ratio were significantly reduced by zerumbone pretreatment, but the drug failed to influence the histological parameters of pancreatitis. The anti-inflammatory effects of the drug were manifested in decreases in the cytosolic interleukin 6 and tumor necrosis factor α concentrations and an elevation in the I-κB concentration, whereas the antioxidant ability of zerumbone was demonstrated by reductions in inducible nitric oxide synthase, Mn- and Cu/Zn-superoxide dismutase activities in the zerumbone-treated rats. CONCLUSION: Zerumbone ameliorated the changes of several parameters of acute pancreatitis probably by interfering with I-κB degradation, but in the applied dose, it failed to influence the histology of the disease.",
keywords = "Pancreatitis, Rat, Zerumbone",
author = "Annam{\'a}ria Szabolcs and L. Tiszlavicz and J. Kaszaki and A. P{\'o}sa and A. Berk{\'o} and I. Varga and I. Boros and V. Szűts and J. Lonovics and T. Tak{\'a}cs",
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T1 - Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology

AU - Szabolcs, Annamária

AU - Tiszlavicz, L.

AU - Kaszaki, J.

AU - Pósa, A.

AU - Berkó, A.

AU - Varga, I.

AU - Boros, I.

AU - Szűts, V.

AU - Lonovics, J.

AU - Takács, T.

PY - 2007/10

Y1 - 2007/10

N2 - OBJECTIVE: Our experiments were designed to investigate the effects of zerumbone pretreatment on cholecystokinin octapeptide (CCK-8)-induced acute pancreatitis in rats. METHODS: Male Wistar rats weighing 240 to 280 g were divided into a control group, a group treated with CCK-8, a group receiving 20 mg/kg zerumbone before CCK-8 administration, and a group treated with zerumbone only. RESULTS: The serum amylase and lipase activities and the pancreatic weight-body weight ratio were significantly reduced by zerumbone pretreatment, but the drug failed to influence the histological parameters of pancreatitis. The anti-inflammatory effects of the drug were manifested in decreases in the cytosolic interleukin 6 and tumor necrosis factor α concentrations and an elevation in the I-κB concentration, whereas the antioxidant ability of zerumbone was demonstrated by reductions in inducible nitric oxide synthase, Mn- and Cu/Zn-superoxide dismutase activities in the zerumbone-treated rats. CONCLUSION: Zerumbone ameliorated the changes of several parameters of acute pancreatitis probably by interfering with I-κB degradation, but in the applied dose, it failed to influence the histology of the disease.

AB - OBJECTIVE: Our experiments were designed to investigate the effects of zerumbone pretreatment on cholecystokinin octapeptide (CCK-8)-induced acute pancreatitis in rats. METHODS: Male Wistar rats weighing 240 to 280 g were divided into a control group, a group treated with CCK-8, a group receiving 20 mg/kg zerumbone before CCK-8 administration, and a group treated with zerumbone only. RESULTS: The serum amylase and lipase activities and the pancreatic weight-body weight ratio were significantly reduced by zerumbone pretreatment, but the drug failed to influence the histological parameters of pancreatitis. The anti-inflammatory effects of the drug were manifested in decreases in the cytosolic interleukin 6 and tumor necrosis factor α concentrations and an elevation in the I-κB concentration, whereas the antioxidant ability of zerumbone was demonstrated by reductions in inducible nitric oxide synthase, Mn- and Cu/Zn-superoxide dismutase activities in the zerumbone-treated rats. CONCLUSION: Zerumbone ameliorated the changes of several parameters of acute pancreatitis probably by interfering with I-κB degradation, but in the applied dose, it failed to influence the histology of the disease.

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