Zaprinast, cicletanine, and verapamil attenuate overdrive pacing-induced myocardial ischemia in conscious rabbits

Z. Szilvássy, Ildiko Jakab, P. Ferdinándy, Matyas Koltai, J. Lonovics, Thierry Tarrade, Pierre G. Braquet

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In conscious rabbits equipped with right ventricular electrode and left ventricular polyethylene catheters, zaprinast and cicletanine, inhibitors of phosphodiesterase (PDE) V and PDEs I and V, respectively, as well as verapamil, a Ca2+ channel blocker, decreased intracavital ST-segment elevation induced by ventricular overdrive pacing (VOP). Zaprinast and cicletanine attenuated VOP-induced QT reduction and increase in left ventricular end-diastolic pressure (LVEDP), whereas verapamil increased LVEDP. These results suggest that inhibition of cGMP-PDEs can protect heart against ischemia.

Original languageEnglish
JournalLife Sciences
Volume53
Issue number1
DOIs
Publication statusPublished - 1993

Fingerprint

Verapamil
Myocardial Ischemia
Type 5 Cyclic Nucleotide Phosphodiesterases
Rabbits
Blood Pressure
Catheters
Polyethylene
Electrodes
Ischemia
cicletanine
zaprinast

ASJC Scopus subject areas

  • Pharmacology

Cite this

Zaprinast, cicletanine, and verapamil attenuate overdrive pacing-induced myocardial ischemia in conscious rabbits. / Szilvássy, Z.; Jakab, Ildiko; Ferdinándy, P.; Koltai, Matyas; Lonovics, J.; Tarrade, Thierry; Braquet, Pierre G.

In: Life Sciences, Vol. 53, No. 1, 1993.

Research output: Contribution to journalArticle

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AU - Szilvássy, Z.

AU - Jakab, Ildiko

AU - Ferdinándy, P.

AU - Koltai, Matyas

AU - Lonovics, J.

AU - Tarrade, Thierry

AU - Braquet, Pierre G.

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