Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast

Yu Wu Xiong, Hong Liu Xiao, Cheng Lin Yong, Hui Luo Jing, Gang She Zhi, Li Houjin, Lai Chan Wing, S. Antus, T. Kurtán, Brigitta Elsässer, Karsten Krohn

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Xyloketal F (1), an unusual metabolite with strong L-calcium channel blocking activity, was isolated from the mangrove endophytic fungus Xylaria sp. (#2508) collected at the South China Sea coast. Its structure was elucidated by spectral and single-crystal X-ray diffraction analysis. The absolute configuration of 1 was determined by the method of quantum-mechanical calculation of CD spectra. Compound 1 was also synthesized by condensation of xyloketal B with formaldehyde. The L-calcium channel blocking activities of xyloketals B, A, and F were determined, and at the same concentration (0.03 μmol/L), the inhibiting rates were 12.05 %, 21.47 %, and 50.33 % respectively.

Original languageEnglish
Pages (from-to)4061-4064
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number19
DOIs
Publication statusPublished - Sep 26 2005

Fingerprint

Calcium Channel Blockers
Calcium Channels
Fungi
Oceans and Seas
Coastal zones
China
Metabolites
X-Ray Diffraction
X ray diffraction analysis
Formaldehyde
Condensation
Single crystals
xyloketal B

Keywords

  • Absolute configuration
  • CD calculation
  • Fungal metabolites
  • L-Calcium channel blocker
  • Quantum-mechanical
  • Semi synthesis
  • Xylaria sp.
  • Xyloketal F

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Xyloketal F : A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast. / Xiong, Yu Wu; Xiao, Hong Liu; Yong, Cheng Lin; Jing, Hui Luo; Zhi, Gang She; Houjin, Li; Wing, Lai Chan; Antus, S.; Kurtán, T.; Elsässer, Brigitta; Krohn, Karsten.

In: European Journal of Organic Chemistry, No. 19, 26.09.2005, p. 4061-4064.

Research output: Contribution to journalArticle

Xiong, Yu Wu ; Xiao, Hong Liu ; Yong, Cheng Lin ; Jing, Hui Luo ; Zhi, Gang She ; Houjin, Li ; Wing, Lai Chan ; Antus, S. ; Kurtán, T. ; Elsässer, Brigitta ; Krohn, Karsten. / Xyloketal F : A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast. In: European Journal of Organic Chemistry. 2005 ; No. 19. pp. 4061-4064.
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abstract = "Xyloketal F (1), an unusual metabolite with strong L-calcium channel blocking activity, was isolated from the mangrove endophytic fungus Xylaria sp. (#2508) collected at the South China Sea coast. Its structure was elucidated by spectral and single-crystal X-ray diffraction analysis. The absolute configuration of 1 was determined by the method of quantum-mechanical calculation of CD spectra. Compound 1 was also synthesized by condensation of xyloketal B with formaldehyde. The L-calcium channel blocking activities of xyloketals B, A, and F were determined, and at the same concentration (0.03 μmol/L), the inhibiting rates were 12.05 {\%}, 21.47 {\%}, and 50.33 {\%} respectively.",
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AU - Houjin, Li

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