Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast

Yu Wu Xiong, Hong Liu Xiao, Cheng Lin Yong, Hui Luo Jing, Gang She Zhi, Li Houjin, Lai Chan Wing, Sándor Antus, Tibor Kurtan, Brigitta Elsässer, Karsten Krohn

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19 Citations (Scopus)

Abstract

Xyloketal F (1), an unusual metabolite with strong L-calcium channel blocking activity, was isolated from the mangrove endophytic fungus Xylaria sp. (#2508) collected at the South China Sea coast. Its structure was elucidated by spectral and single-crystal X-ray diffraction analysis. The absolute configuration of 1 was determined by the method of quantum-mechanical calculation of CD spectra. Compound 1 was also synthesized by condensation of xyloketal B with formaldehyde. The L-calcium channel blocking activities of xyloketals B, A, and F were determined, and at the same concentration (0.03 μmol/L), the inhibiting rates were 12.05 %, 21.47 %, and 50.33 % respectively.

Original languageEnglish
Pages (from-to)4061-4064
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number19
DOIs
Publication statusPublished - Sep 26 2005

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Keywords

  • Absolute configuration
  • CD calculation
  • Fungal metabolites
  • L-Calcium channel blocker
  • Quantum-mechanical
  • Semi synthesis
  • Xylaria sp.
  • Xyloketal F

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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