Xenon chloride ultraviolet B laser is more effective in treating psoriasis and in inducing T cell apoptosis than narrow-band ultraviolet B

Zoltán Novák, Béla Bónis, Eszter Baltás, Imre Ocsovszki, Ferenc Ignácz, Attila Dobozy, Lajos Kemény

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Earlier we reported that a 308-nm xenon chloride (XeC1) UVB laser is highly effective for treating psoriasis. As ultraviolet B light seems to cause T cell apoptosis, in the present study we studied the ability of the XeC1 laser to induce T-cell apoptosis in vitro, and then compared the apoptosis-inducing capacities of narrow-band UVB (NB-UVB) light and the XeC1 laser. The role of laser impulse frequency and intensity in the therapeutical and apoptosis-inducing efficacy of XeC1 laser was also investigated. Both XeC1 laser and NB-UVB induced T cell apoptosis, but quantitative induction was greater with XeC1 laser. Changes in the frequency and intensity of impulses of XeC1 laser did not influence its therapeutic and T cell apoptosis-inducing efficacy. These results suggest that the more effective induction of T cell apoptosis can be responsible for the greater clinical efficacy of XeC1 laser compared to NB-UVB. Additionally, the optical properties of the XeC1 laser (a monochromatic, coherent, pulse-mode laser; easier precise dosimetry, there are no 'contaminating' wavelengths) can make this laser light an ideal tool for studies of the mode of action of UVB light.

Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalJournal of Photochemistry and Photobiology B: Biology
Volume67
Issue number1
DOIs
Publication statusPublished - Jun 3 2002

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Keywords

  • Apoptosis
  • Psoriasis
  • T cells
  • Ultraviolet B

ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

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