Xanthine oxidase inhibitory activity of hungarian wild-growing mushrooms

Attila Ványolõs, Orsolya Orbán-Gyapai, Judit Hohmann

Research output: Contribution to journalArticle

7 Citations (Scopus)


Mushrooms represent a remarkable and yet largely unexplored source of new, biologically active natural products. In this work, we report on the xanthine oxidase (XO) inhibitory activity of 47 wild-growing mushrooms native to Hungary. Aqueous and organic (n-hexane, chloroform, and 50% methanol) extracts of selected mushrooms from different families were screened for their XO inhibitory activities. Among the 188 extracts investigated, the chloroform and 50% methanol fractions proved to be the most effective. Some species exhibited high inhibitory activity, e.g., Hypholoma fasciculare (IC50-=-67.76- ±-11.05-μg/mL), Suillus grevillei (IC50-=-13.28-±-1. 58-μg/mL), and Tricholoma populinum (IC50-=-85.08-±-15.02- μg/mL); others demonstrated moderate or weak activity. Additional studies are warranted to characterize the compounds responsible for the XO inhibitory activity of mushroom extracts.

Original languageEnglish
Pages (from-to)1204-1210
Number of pages7
JournalPhytotherapy Research
Issue number8
Publication statusPublished - Aug 2014


  • mushroom
  • screening
  • xanthine oxidase

ASJC Scopus subject areas

  • Pharmacology

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