Xanthine oxidase inhibitory activity of extracts prepared from polygonaceae species

Orsolya Orbán-Gyapai, Ildikó Lajter, J. Hohmann, Gusztáv Jakab, A. Vasas

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The xanthine oxidase (XO) inhibitory activity of aqueous and organic extracts of 27 selected species belonging in five genera (Fallopia, Oxyria, Persicaria, Polygonum and Rumex) of the family Polygonaceae occurring in the Carpathian Basin were tested in vitro. From different plant parts (aerial parts, leaves, flowers, fruits and roots), a total of 196 extracts were prepared by subsequent extraction with methanol and hot H2O and solvent-solvent partition of the MeOH extract yielding n-hexane, chloroform and 50% MeOH subextracts. It was found that the chloroform subextracts and/or the remaining 50% MeOH extracts of Fallopia species (F. bohemica, F. japonica and F. sachalinensis), Rumex species (R. acetosa, R. acetosella, R. alpinus, R. conglomeratus, R. crispus, R. hydrolapathus, R. pulcher, R. stenophyllus, R. thyrsiflorus, R. obtusifolius subsp. subalpinus, R. patientia) and Polygonum bistorta, Polygonum hydropiper, Polygonum lapathifolium and Polygonum viviparum demonstrated the highest XO inhibitory activity (>85% inhibition) at 400 μg/mL. The IC50 values of the active extracts were also determined. On the basis of the results, these plants, and especially P. hydropiper and R. acetosella, are considered worthy of activity-guided phytochemical investigations.

Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalPhytotherapy Research
Volume29
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

Polygonaceae
Polygonum
Xanthine Oxidase
Rumex
Chloroform
Aerial Plant Components
Phytochemicals
Inhibitory Concentration 50
Methanol
Fruit

Keywords

  • Fallopia
  • Persicaria species
  • Polygonaceae
  • Polygonum
  • Rumex
  • xanthine oxidase inhibitory activity

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Xanthine oxidase inhibitory activity of extracts prepared from polygonaceae species. / Orbán-Gyapai, Orsolya; Lajter, Ildikó; Hohmann, J.; Jakab, Gusztáv; Vasas, A.

In: Phytotherapy Research, Vol. 29, No. 3, 2015, p. 459-465.

Research output: Contribution to journalArticle

Orbán-Gyapai, Orsolya ; Lajter, Ildikó ; Hohmann, J. ; Jakab, Gusztáv ; Vasas, A. / Xanthine oxidase inhibitory activity of extracts prepared from polygonaceae species. In: Phytotherapy Research. 2015 ; Vol. 29, No. 3. pp. 459-465.
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