Wound healing and glaucoma surgery

Modulating the scarring process with conventional antimetabolites and new molecules

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Citations (Scopus)

Abstract

Subconjunctival absorption of aqueous humor is an essential part of glaucoma filtration surgery. Mitomycin C (MMC) and 5-fluorouracil have been used to reduce postoperative episcleral fibrosis and scar formation in the filtering bleb area for more than two decades. Both antimetabolites have also been frequently injected before needling revision of failing filtering blebs. Recently, MMC was tried also in tube surgery and nonpenetrating filtering surgery, but its usefulness in these applications has not yet been determined. The main complications and side effects of antimetaboliteenhanced filtration surgery comprise development of thin-walled cystic blebs, late bleb leaks, bleb infections, endophthalmitis, chronic hypotony, hypotony maculopathy and corneal epithelial toxicity. Besides MMC and 5-fluorouracil, several other agents were proposed for decreasing episcleral healing after glaucoma filtering surgery. Only few were evaluated in randomized clinical trials, and none became generally accepted or widely used.

Original languageEnglish
Title of host publicationGlaucoma Surgery
PublisherS. Karger AG
Pages79-89
Number of pages11
Volume50
ISBN (Print)9783805599382, 9783805599375
DOIs
Publication statusPublished - Apr 20 2012

Fingerprint

Antimetabolites
Filtering Surgery
Blister
Glaucoma
Wound Healing
Surgery
Cicatrix
Mitomycin
Molecules
Fluorouracil
Endophthalmitis
Aqueous Humor
Fibrosis
Randomized Controlled Trials
Toxicity
Infection

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wound healing and glaucoma surgery : Modulating the scarring process with conventional antimetabolites and new molecules. / Holló, G.

Glaucoma Surgery. Vol. 50 S. Karger AG, 2012. p. 79-89.

Research output: Chapter in Book/Report/Conference proceedingChapter

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