Would eating carrots protect your liver? A new role involving NKT cells for retinoic acid in hepatitis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Retinoic acid (RA), which is the biologically active form of vitamin A, acts through the nuclear hormone receptor RAR (RA receptor) to induce either gene activation or repression. RA production and its effects have been linked to macrophages, dendritic cells, T and B cells, and iNKT cells in the immune system and play pro- as well as anti-inflammatory roles depending on the cell type and the immune context. In this issue of the European Journal of Immunology, Lee et al. [] show that RA ameliorates Con A-induced murine hepatitis by selectively downmodulating IFN-γ and IL-4 production in disease-causing NKT cells in the liver. Remarkably, this effect is restricted to this liver disease model and does not apply to αGalCer-induced murine liver injury, which is driven by other cytokines. The study identifies retinoid signaling as an important endogenous mechanism controlling immune reactions and also as a potential pharmacological target for treatment of hepatic liver injury. Furthermore, the study by Lee et al. provides additional support for the concept of metabolic regulation of immune function.

Original languageEnglish
Pages (from-to)1677-1680
Number of pages4
JournalEuropean Journal of Immunology
Volume42
Issue number7
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Daucus carota
Natural Killer T-Cells
Tretinoin
Hepatitis
Eating
Liver
Retinoic Acid Receptors
Retinoids
Wounds and Injuries
Cytoplasmic and Nuclear Receptors
Allergy and Immunology
Vitamin A
Interleukin-4
Dendritic Cells
Transcriptional Activation
Liver Diseases
Immune System
B-Lymphocytes
Anti-Inflammatory Agents
Macrophages

Keywords

  • Hepatitis
  • NKT cells
  • RAR
  • Retinoids

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Would eating carrots protect your liver? A new role involving NKT cells for retinoic acid in hepatitis. / Nagy, L.

In: European Journal of Immunology, Vol. 42, No. 7, 07.2012, p. 1677-1680.

Research output: Contribution to journalArticle

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