Worldwide human mitochondrial haplogroup distribution from urban sewage

Orsolya Anna Pipek, Anna Medgyes-Horváth, L. Dobos, József Stéger, János Szalai-Gindl, Dávid Visontai, Rolf S. Kaas, Marion Koopmans, Rene S. Hendriksen, Frank M. Aarestrup, I. Csabai

Research output: Contribution to journalArticle

Abstract

Community level genetic information can be essential to direct health measures and study demographic tendencies but is subject to considerable ethical and legal challenges. These concerns become less pronounced when analyzing urban sewage samples, which are ab ovo anonymous by their pooled nature. We were able to detect traces of the human mitochondrial DNA (mtDNA) in urban sewage samples and to estimate the distribution of human mtDNA haplogroups. An expectation maximization approach was used to determine mtDNA haplogroup mixture proportions for samples collected at each different geographic location. Our results show reasonable agreement with both previous studies of ancient evolution or migration and current US census data; and are also readily reproducible and highly robust. Our approach presents a promising alternative for sample collection in studies focusing on the ethnic and genetic composition of populations or diseases associated with different mtDNA haplogroups and genotypes.

Original languageEnglish
Article number11624
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

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mitochondrial DNA
sewage
census
genotype
distribution

ASJC Scopus subject areas

  • General

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Pipek, O. A., Medgyes-Horváth, A., Dobos, L., Stéger, J., Szalai-Gindl, J., Visontai, D., ... Csabai, I. (2019). Worldwide human mitochondrial haplogroup distribution from urban sewage. Scientific reports, 9(1), [11624]. https://doi.org/10.1038/s41598-019-48093-5

Worldwide human mitochondrial haplogroup distribution from urban sewage. / Pipek, Orsolya Anna; Medgyes-Horváth, Anna; Dobos, L.; Stéger, József; Szalai-Gindl, János; Visontai, Dávid; Kaas, Rolf S.; Koopmans, Marion; Hendriksen, Rene S.; Aarestrup, Frank M.; Csabai, I.

In: Scientific reports, Vol. 9, No. 1, 11624, 01.12.2019.

Research output: Contribution to journalArticle

Pipek, OA, Medgyes-Horváth, A, Dobos, L, Stéger, J, Szalai-Gindl, J, Visontai, D, Kaas, RS, Koopmans, M, Hendriksen, RS, Aarestrup, FM & Csabai, I 2019, 'Worldwide human mitochondrial haplogroup distribution from urban sewage', Scientific reports, vol. 9, no. 1, 11624. https://doi.org/10.1038/s41598-019-48093-5
Pipek OA, Medgyes-Horváth A, Dobos L, Stéger J, Szalai-Gindl J, Visontai D et al. Worldwide human mitochondrial haplogroup distribution from urban sewage. Scientific reports. 2019 Dec 1;9(1). 11624. https://doi.org/10.1038/s41598-019-48093-5
Pipek, Orsolya Anna ; Medgyes-Horváth, Anna ; Dobos, L. ; Stéger, József ; Szalai-Gindl, János ; Visontai, Dávid ; Kaas, Rolf S. ; Koopmans, Marion ; Hendriksen, Rene S. ; Aarestrup, Frank M. ; Csabai, I. / Worldwide human mitochondrial haplogroup distribution from urban sewage. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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