WNT signaling - lung cancer is no exception

Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei, Judit E. Pongracz

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the various effects of activation and inhibition of the WNT signaling pathways are summarized in the context of lung carcinogenesis. Recent evidence regarding WNT ligand transport mechanisms, the role of WNT signaling in lung cancer angiogenesis and drug transporter regulation and the importance of microRNA and posttranscriptional regulation of WNT signaling are also reviewed.

Original languageEnglish
Article number167
JournalRespiratory Research
Volume18
Issue number1
DOIs
Publication statusPublished - Sep 5 2017

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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