Widespread increased expression of the DNA repair enzyme PARP in brain in ALS

S. H. Kim, J. Engelhardt, J. S. Henkel, L. Siklós, J. Soós, C. Goodman, S. H. Appel

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Expression of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) is a known response to oxidative damage of DNA. In ALS brain, PARP expression by western analyses was increased in the motor cortex, parietal cortex, and cerebellum. PARP immunostaining in the motor cortex was increased in ALS neurons and subcortical glia and macrophages. Importantly, there was widespread increased PARP expression in neurons in the parietal cortex and cerebellum, regions that are typically clinically unaffected in ALS, suggesting widespread oxidative stress.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalNeurology
Volume62
Issue number2
Publication statusPublished - Jan 27 2004

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DNA Repair Enzymes
Poly(ADP-ribose) Polymerases
Parietal Lobe
Motor Cortex
Brain
Cerebellum
Neurons
Neuroglia
DNA Damage
Oxidative Stress
Macrophages

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kim, S. H., Engelhardt, J., Henkel, J. S., Siklós, L., Soós, J., Goodman, C., & Appel, S. H. (2004). Widespread increased expression of the DNA repair enzyme PARP in brain in ALS. Neurology, 62(2), 319-322.

Widespread increased expression of the DNA repair enzyme PARP in brain in ALS. / Kim, S. H.; Engelhardt, J.; Henkel, J. S.; Siklós, L.; Soós, J.; Goodman, C.; Appel, S. H.

In: Neurology, Vol. 62, No. 2, 27.01.2004, p. 319-322.

Research output: Contribution to journalArticle

Kim, SH, Engelhardt, J, Henkel, JS, Siklós, L, Soós, J, Goodman, C & Appel, SH 2004, 'Widespread increased expression of the DNA repair enzyme PARP in brain in ALS', Neurology, vol. 62, no. 2, pp. 319-322.
Kim SH, Engelhardt J, Henkel JS, Siklós L, Soós J, Goodman C et al. Widespread increased expression of the DNA repair enzyme PARP in brain in ALS. Neurology. 2004 Jan 27;62(2):319-322.
Kim, S. H. ; Engelhardt, J. ; Henkel, J. S. ; Siklós, L. ; Soós, J. ; Goodman, C. ; Appel, S. H. / Widespread increased expression of the DNA repair enzyme PARP in brain in ALS. In: Neurology. 2004 ; Vol. 62, No. 2. pp. 319-322.
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