Whole genome sequencing of a rare rotavirus from archived stool sample demonstrates independent zoonotic origin of human G8P[14] strains in Hungary

Szilvia Marton, Renáta Dóró, Enikő Fehér, Barbara Forró, Katalin Ihász, Renáta Varga-Kugler, Szilvia L. Farkas, K. Bányai

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6 Citations (Scopus)

Abstract

Genotype P[14] rotaviruses in humans are thought to be zoonotic strains originating from bovine or ovine host species. Over the past 30 years only few genotype P[14] strains were identified in Hungary totaling <0.1% of all human rotaviruses whose genotype had been determined. In this study we report the genome sequence and phylogenetic analysis of a human genotype G8P[14] strain, RVA/Human-wt/HUN/182-02/2001/G8P[14]. The whole genome constellation (G8-P[14]-I2-R2-C2-M2-A11-N2-T6-E2-H3) of this strain was shared with another Hungarian zoonotic G8P[14] strain, RVA/Human-wt/HUN/BP1062/2004/G8P[14], although phylogenetic analyses revealed the two rotaviruses likely had different progenitors. Overall, our findings indicate that human G8P[14] rotavirus detected in Hungary in the past originated from independent zoonotic events. Further studies are needed to assess the public health risk associated with infections by various animal rotavirus strains.

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalVirus Research
Volume227
DOIs
Publication statusPublished - Jan 2 2017

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Keywords

  • Genetic diversity
  • Phylogenetic analysis
  • Reassortment
  • Rotavirus A
  • Viral zoonosis

ASJC Scopus subject areas

  • Cancer Research
  • Infectious Diseases
  • Virology

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