Whole genome sequence of a goose haemorrhagic polyomavirus detected in Hungary

Eniko Fehér, György Lengyel, A. Dán, Szilvia L. Farkas, K. Bányai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Goose haemorrhagic polyomavirus (GHPV) provoke haemorrhagic nephritis and enteritis of domestic geese. Outbreaks were detected in European countries and caused economic losses for goose keepers. Domestic ducks may be infected with GHPV without any signs typical for geese. The genomic organisation of some isolates was described but the gene functions and the pathomechanisms of the virus was not precisely defined. Here we describe the genome sequence and structure of GHPV of a goose from a Hungarian goose flock showing characteristics of the haemorrhagic nephritis and enteritis. The GHPV genome investigated in this study was 5252 bp long and was very similar (99% nucleotide identity) to sequences deposited in the GenBank. All the whole GHPV genomes possess the same ORFs in length, including the VP1, VP2, VP3, ORF-X, t and T tumour antigens. Amino acid changes are detected mainly in the putative ORF-X region. Data about the GHPV genome imply a conserved genomic structure among isolates from different countries. Genomic and epidemiological studies may help vaccine development efforts and identify potential heterologous reservoirs of GHPV.

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalActa Microbiologica et Immunologica Hungarica
Volume61
Issue number2
DOIs
Publication statusPublished - Jun 1 2014

Fingerprint

Geese
Polyomavirus
Hungary
Genome
Open Reading Frames
Enteritis
Nephritis
Ducks
Viral Tumor Antigens
Nucleic Acid Databases
Neoplasm Antigens
Disease Outbreaks
Epidemiologic Studies
Vaccines

Keywords

  • duck
  • goose
  • haemorrhagic nephritis and enteritis
  • polyomaviruses
  • vaccine development

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Whole genome sequence of a goose haemorrhagic polyomavirus detected in Hungary. / Fehér, Eniko; Lengyel, György; Dán, A.; Farkas, Szilvia L.; Bányai, K.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 61, No. 2, 01.06.2014, p. 221-227.

Research output: Contribution to journalArticle

Fehér, Eniko ; Lengyel, György ; Dán, A. ; Farkas, Szilvia L. ; Bányai, K. / Whole genome sequence of a goose haemorrhagic polyomavirus detected in Hungary. In: Acta Microbiologica et Immunologica Hungarica. 2014 ; Vol. 61, No. 2. pp. 221-227.
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