Whole body hypothermia and oxidative stress in babies with hypoxic-ischemic brain injury

Serafina Perrone, Miklós Szabó, Carlo Valerio Bellieni, Mariangela Longini, Márta Bangó, Dorottya Kelen, András Treszl, Simona Negro, Maria Luisa Tataranno, Giuseppe Buonocore

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42 Citations (Scopus)

Abstract

According to increasing evidence, hypothermia can significantly improve outcomes in term neonates manifesting asphyxic insult and hypoxic-ischemic encephalopathy. Oxidative stress plays a key role in hypoxic-ischemic and inflammatory brain injuries. We investigated the impact of hypothermia on oxidative stress in babies with hypoxic-ischemic encephalopathy. Term infants were randomly selected for treatment with moderate whole body hypothermia or standard care on normothermia, after perinatal asphyxia. Total hydroperoxides as biochemical markers of oxidative stress, and C-reactive protein as a marker of inflammation, were assayed in blood samples drown at 6, 12, 24, 48, and 72 postnatal hours. In both hypothermic and normothermic groups, total hydroperoxides and C-reactive protein exhibited a continuous increase in the first days after birth. Nevertheless, a tendency was evident for slower and smaller elevations of total hydroperoxides and C-reactive protein in hypothermic compared with normothermic infants. A significant correlation was observed between total hydroperoxides and C-reactive protein in all patients, indicating an association between inflammation and oxidative stress during asphyxia. The slower increase and lower peaks of total hydroperoxides in the hypothermic group support the hypothesis that postasphyxic oxidative stress may be reduced by hypothermia.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalPediatric Neurology
Volume43
Issue number4
DOIs
Publication statusPublished - Oct 2010

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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    Perrone, S., Szabó, M., Bellieni, C. V., Longini, M., Bangó, M., Kelen, D., Treszl, A., Negro, S., Tataranno, M. L., & Buonocore, G. (2010). Whole body hypothermia and oxidative stress in babies with hypoxic-ischemic brain injury. Pediatric Neurology, 43(4), 236-240. https://doi.org/10.1016/j.pediatrneurol.2010.05.009