White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

Alan J. Burns, Allan M. Goldstein, Donald F. Newgreen, Lincon Stamp, Karl Herbert Schäfer, Marco Metzger, Ryo Hotta, Heather M. Young, Peter W. Andrews, Nikhil Thapar, Jaime Belkind-Gerson, Nadege Bondurand, Joel C. Bornstein, Wood Yee Chan, Kathryn Cheah, Michael D. Gershon, Robert O. Heuckeroth, Robert M.W. Hofstra, Lothar Just, Raj P. KapurSebastian K. King, Conor J. McCann, Nandor Nagy, Elly Ngan, Florian Obermayr, Vassilis Pachnis, Pankaj J. Pasricha, Mai Har Sham, Paul Tam, Pieter Vanden Berghe

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.

Original languageEnglish
Pages (from-to)229-251
Number of pages23
JournalDevelopmental Biology
Volume417
Issue number2
DOIs
Publication statusPublished - Sep 15 2016

Keywords

  • Cell replacement therapy
  • Enteric nervous system
  • Enteric neuropathies
  • Hirschsprung disease
  • Stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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  • Cite this

    Burns, A. J., Goldstein, A. M., Newgreen, D. F., Stamp, L., Schäfer, K. H., Metzger, M., Hotta, R., Young, H. M., Andrews, P. W., Thapar, N., Belkind-Gerson, J., Bondurand, N., Bornstein, J. C., Chan, W. Y., Cheah, K., Gershon, M. D., Heuckeroth, R. O., Hofstra, R. M. W., Just, L., ... Vanden Berghe, P. (2016). White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology, 417(2), 229-251. https://doi.org/10.1016/j.ydbio.2016.04.001