White-matter microstructure and language lateralization in left-handers: A whole-brain MRI analysis

Gabor Perlaki, Reka Horvath, Gergely Orsi, Mihaly Aradi, Tibor Auer, Eszter Varga, Gyongyi Kantor, Anna Altbäcker, Flora John, T. Dóczi, S. Komoly, N. Kovács, Attila Schwarcz, J. Janszky

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Most people are left-hemisphere dominant for language. However the neuroanatomy of language lateralization is not fully understood. By combining functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), we studied whether language lateralization is associated with cerebral white-matter (WM) microstructure. Sixteen healthy, left-handed women aged 20-25 were included in the study. Left-handers were targeted in order to increase the chances of involving subjects with atypical language lateralization. Language lateralization was determined by fMRI using a verbal fluency paradigm. Tract-based spatial statistics analysis of DTI data was applied to test for WM microstructural correlates of language lateralization across the whole brain. Fractional anisotropy and mean diffusivity were used as indicators of WM microstructural organization. Right-hemispheric language dominance was associated with reduced microstructural integrity of the left superior longitudinal fasciculus and left-sided parietal lobe WM. In left-handed women, reduced integrity of the left-sided language related tracts may be closely linked to the development of right hemispheric language dominance. Our results may offer new insights into language lateralization and structure-function relationships in human language system.

Original languageEnglish
Pages (from-to)319-328
Number of pages10
JournalBrain and Cognition
Volume82
Issue number3
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Language
Brain
Diffusion Tensor Imaging
White Matter
Language Lateralization
Microstructure
Magnetic Resonance Imaging
Neuroanatomy
Parietal Lobe
Spatial Analysis
Anisotropy
Language Dominance
Functional Magnetic Resonance Imaging
Imaging
Integrity

Keywords

  • Atypical speech laterality
  • Diffusion tensor imaging
  • Functional magnetic resonance imaging
  • Left-handers
  • Superior longitudinal fasciculus
  • Superior parietal lobe

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

White-matter microstructure and language lateralization in left-handers : A whole-brain MRI analysis. / Perlaki, Gabor; Horvath, Reka; Orsi, Gergely; Aradi, Mihaly; Auer, Tibor; Varga, Eszter; Kantor, Gyongyi; Altbäcker, Anna; John, Flora; Dóczi, T.; Komoly, S.; Kovács, N.; Schwarcz, Attila; Janszky, J.

In: Brain and Cognition, Vol. 82, No. 3, 08.2013, p. 319-328.

Research output: Contribution to journalArticle

Perlaki, G, Horvath, R, Orsi, G, Aradi, M, Auer, T, Varga, E, Kantor, G, Altbäcker, A, John, F, Dóczi, T, Komoly, S, Kovács, N, Schwarcz, A & Janszky, J 2013, 'White-matter microstructure and language lateralization in left-handers: A whole-brain MRI analysis', Brain and Cognition, vol. 82, no. 3, pp. 319-328. https://doi.org/10.1016/j.bandc.2013.05.005
Perlaki, Gabor ; Horvath, Reka ; Orsi, Gergely ; Aradi, Mihaly ; Auer, Tibor ; Varga, Eszter ; Kantor, Gyongyi ; Altbäcker, Anna ; John, Flora ; Dóczi, T. ; Komoly, S. ; Kovács, N. ; Schwarcz, Attila ; Janszky, J. / White-matter microstructure and language lateralization in left-handers : A whole-brain MRI analysis. In: Brain and Cognition. 2013 ; Vol. 82, No. 3. pp. 319-328.
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