White matter hyperintensities and depression - Preliminary results from the LADIS study

Michael J. Firbank, John T. O'Brien, Sanjeet Pakrasi, Leonardo Pantoni, Michela Simoni, Timo Erkinjuntti, Anders Wallin, Lars Olof Wahlund, I. van Straaten, Domenico Inzitari, Philip Scheletens, Frederik Barkhof, A. Klijn Velderman, Zoltán Nagy, Zsolt May, Csaba Óváry, Peter Barsi, Ilona Pataky, Gunhild Waldermar, Ellen GardeEgill Rostrup, Charlotte Ryberg, Asmus Vogel, Olaf Paulson, Anne Mette Hejl, Oda Jakobsen, Aleksandra Klimkowicz, Magdalena Bosak, Dorota Szwabowska, Anne Maria Basile, Luciano Bartolini, Emilia Salvatori, Marco Moretti, Mario Mascalchi, Giovanni Pracucci, Patrizia Trallori, Michael Jonsson, Kerstini Gustavsson, Arto Nordlund, Sindre Rolstad, Åke Edman, Karin Lind, Sven Ekholm, Sussane Ribbelin, Franz Fazekas, Reinhold Schmidt, Ulrike Trummer, Steffan Ropele, Katjia Petrovic, Pia Pihanen, Tarja Pohjasvaaran, Meija Marjut Somerkoski, Elisa Iiovonen, Riitta Mäntylä, Raija Ylikoski, Milita Crisby, Eleonore Rydén, Kaarina Amberla, Lena Bronge, Anna Pettersson, Anette Eidehall, Julien Bogousslavski, Joseph Ghika, José Ferro, Sofia Madureira, Ana Verdelho, Carlos Garcia, Carlos Morgado, Micheal Hennerici, Hans Juergen Baezner, Christian Blahak, A. Grass, K. Fassbender, O. Mielke, Jochen Gaa, Jochen Hirsch, S. Behrens, Wiarda, Thais Minnett, Pascale Harrison, Anil Gholkar, Huges Chanriat, Ludovic Benoist, Karen Hernandez

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Abstract

Background: White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood. Methods: In a pan-European multicentre study of 629 older subjects, we examined the relationship between MRI white matter hyperintensities (WMH), depressive symptoms and self perceived health quality of life (QOL). WMH were rated using a three-point scale. Results: We found depressive symptoms as assessed by the geriatric depression 15-item scale to be associated with WMH rating (Spearman's rho 0.11, p=0.008) and also with the Euro-QOL health score (Spearman's rho -0.5, p<0.001). In a ordinal logistic regression model, QOL was found to strongly predict GDS score (p<0.001) and severe vs mild WMH were associated with increased depression (p=0.028). The relationship between history of severe depression and WMH score was examined, but there were no differences either between those with and without a history of severe depression, or those with an early vs late onset of depression. Conclusions: The results suggest that WMH play a role in increasing depressive symptoms, even when perceived quality of life is controlled for as a possible mediating factor.

Original languageEnglish
Pages (from-to)674-679
Number of pages6
JournalInternational Journal of Geriatric Psychiatry
Volume20
Issue number7
DOIs
Publication statusPublished - Jul 1 2005

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Keywords

  • Depression
  • Elderly
  • MRI
  • White matter hyperintensities

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Firbank, M. J., O'Brien, J. T., Pakrasi, S., Pantoni, L., Simoni, M., Erkinjuntti, T., Wallin, A., Wahlund, L. O., van Straaten, I., Inzitari, D., Scheletens, P., Barkhof, F., Velderman, A. K., Nagy, Z., May, Z., Óváry, C., Barsi, P., Pataky, I., Waldermar, G., ... Hernandez, K. (2005). White matter hyperintensities and depression - Preliminary results from the LADIS study. International Journal of Geriatric Psychiatry, 20(7), 674-679. https://doi.org/10.1002/gps.1342