Which molecularly imprinted polymer is better?

B. Tóth, T. Pap, V. Horváth, G. Horvai

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Molecularly imprinted polymers (MIP) have been successfully synthesized toward many different compounds in the last decades. The mechanistic details of selective binding at binding sites are not yet well understood. For this reason the characterization of MIP binding has been mostly phenomenological and this makes the transfer of results between different laboratories or between different types of applications difficult. In this paper we analyze the relationship between different types of characterization like isotherms, binding site models, chromatographic k and α values, etc. as they relate to different applications like HPLC, solid phase extraction (SPE), binding assays, batch extraction and sensors. It is shown that α values determined by elution chromatography depend on seemingly irrelevant factors as the length and diameter of the column, respectively. The determination of distribution ratios or partition coefficients is proposed as an easily understandable and useful quantity in the characterization of novel MIPs. Data used for the characterization of a MIP should be transferable between different applications but the qualification of MIPs as better or worse will depend on the application in case.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalAnalytica Chimica Acta
Volume591
Issue number1 SPEC. ISS.
DOIs
Publication statusPublished - May 15 2007

Fingerprint

Polymers
polymer
Binding Sites
Solid Phase Extraction
partition coefficient
chromatography
Chromatography
isotherm
High Pressure Liquid Chromatography
assay
sensor
Isotherms
Assays
Sensors
distribution
laboratory

Keywords

  • Distribution ratio
  • Isotherm
  • Molecularly imprinted polymer
  • Partition coefficient

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

Which molecularly imprinted polymer is better? / Tóth, B.; Pap, T.; Horváth, V.; Horvai, G.

In: Analytica Chimica Acta, Vol. 591, No. 1 SPEC. ISS., 15.05.2007, p. 17-21.

Research output: Contribution to journalArticle

Tóth, B. ; Pap, T. ; Horváth, V. ; Horvai, G. / Which molecularly imprinted polymer is better?. In: Analytica Chimica Acta. 2007 ; Vol. 591, No. 1 SPEC. ISS. pp. 17-21.
@article{756da063629148e18ff1a4bddbde1428,
title = "Which molecularly imprinted polymer is better?",
abstract = "Molecularly imprinted polymers (MIP) have been successfully synthesized toward many different compounds in the last decades. The mechanistic details of selective binding at binding sites are not yet well understood. For this reason the characterization of MIP binding has been mostly phenomenological and this makes the transfer of results between different laboratories or between different types of applications difficult. In this paper we analyze the relationship between different types of characterization like isotherms, binding site models, chromatographic k and α values, etc. as they relate to different applications like HPLC, solid phase extraction (SPE), binding assays, batch extraction and sensors. It is shown that α values determined by elution chromatography depend on seemingly irrelevant factors as the length and diameter of the column, respectively. The determination of distribution ratios or partition coefficients is proposed as an easily understandable and useful quantity in the characterization of novel MIPs. Data used for the characterization of a MIP should be transferable between different applications but the qualification of MIPs as better or worse will depend on the application in case.",
keywords = "Distribution ratio, Isotherm, Molecularly imprinted polymer, Partition coefficient",
author = "B. T{\'o}th and T. Pap and V. Horv{\'a}th and G. Horvai",
year = "2007",
month = "5",
day = "15",
doi = "10.1016/j.aca.2007.01.016",
language = "English",
volume = "591",
pages = "17--21",
journal = "Analytica Chimica Acta",
issn = "0003-2670",
publisher = "Elsevier",
number = "1 SPEC. ISS.",

}

TY - JOUR

T1 - Which molecularly imprinted polymer is better?

AU - Tóth, B.

AU - Pap, T.

AU - Horváth, V.

AU - Horvai, G.

PY - 2007/5/15

Y1 - 2007/5/15

N2 - Molecularly imprinted polymers (MIP) have been successfully synthesized toward many different compounds in the last decades. The mechanistic details of selective binding at binding sites are not yet well understood. For this reason the characterization of MIP binding has been mostly phenomenological and this makes the transfer of results between different laboratories or between different types of applications difficult. In this paper we analyze the relationship between different types of characterization like isotherms, binding site models, chromatographic k and α values, etc. as they relate to different applications like HPLC, solid phase extraction (SPE), binding assays, batch extraction and sensors. It is shown that α values determined by elution chromatography depend on seemingly irrelevant factors as the length and diameter of the column, respectively. The determination of distribution ratios or partition coefficients is proposed as an easily understandable and useful quantity in the characterization of novel MIPs. Data used for the characterization of a MIP should be transferable between different applications but the qualification of MIPs as better or worse will depend on the application in case.

AB - Molecularly imprinted polymers (MIP) have been successfully synthesized toward many different compounds in the last decades. The mechanistic details of selective binding at binding sites are not yet well understood. For this reason the characterization of MIP binding has been mostly phenomenological and this makes the transfer of results between different laboratories or between different types of applications difficult. In this paper we analyze the relationship between different types of characterization like isotherms, binding site models, chromatographic k and α values, etc. as they relate to different applications like HPLC, solid phase extraction (SPE), binding assays, batch extraction and sensors. It is shown that α values determined by elution chromatography depend on seemingly irrelevant factors as the length and diameter of the column, respectively. The determination of distribution ratios or partition coefficients is proposed as an easily understandable and useful quantity in the characterization of novel MIPs. Data used for the characterization of a MIP should be transferable between different applications but the qualification of MIPs as better or worse will depend on the application in case.

KW - Distribution ratio

KW - Isotherm

KW - Molecularly imprinted polymer

KW - Partition coefficient

UR - http://www.scopus.com/inward/record.url?scp=34247137589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247137589&partnerID=8YFLogxK

U2 - 10.1016/j.aca.2007.01.016

DO - 10.1016/j.aca.2007.01.016

M3 - Article

C2 - 17456419

AN - SCOPUS:34247137589

VL - 591

SP - 17

EP - 21

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

SN - 0003-2670

IS - 1 SPEC. ISS.

ER -