Where does a migraine attack originate? In the brainstem

J. Tajti, D. Szok, A. Párdutz, B. Tuka, A. Csá Ti, A. Kuris, J. Toldi, L. Vécsei

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Migraine is a common, paroxysmal, highly disabling primary headache disorder. The origin of migraine attacks is enigmatic. Numerous clinical and experimental results suggest that the activation of distinct brainstem nuclei is crucial in its pathogenesis, but the primary cause of this activation is not fully understood. We conclude that the initialization of a migraine attack can be explained as an altered function of the neuronal elements of the brainstem nuclei. In light of our findings and the literature data, we can assume that migraine is a subcortical disorder of a specific brainstem area.

Original languageEnglish
Pages (from-to)557-568
Number of pages12
JournalJournal of Neural Transmission
Volume119
Issue number5
DOIs
Publication statusPublished - May 2012

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Migraine Disorders
Brain Stem
Primary Headache Disorders

Keywords

  • Brainstem
  • Electrophysiology
  • Functional anatomy
  • Kynurenines
  • Migraine
  • Neuroimaging

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Where does a migraine attack originate? In the brainstem. / Tajti, J.; Szok, D.; Párdutz, A.; Tuka, B.; Csá Ti, A.; Kuris, A.; Toldi, J.; Vécsei, L.

In: Journal of Neural Transmission, Vol. 119, No. 5, 05.2012, p. 557-568.

Research output: Contribution to journalArticle

Tajti, J. ; Szok, D. ; Párdutz, A. ; Tuka, B. ; Csá Ti, A. ; Kuris, A. ; Toldi, J. ; Vécsei, L. / Where does a migraine attack originate? In the brainstem. In: Journal of Neural Transmission. 2012 ; Vol. 119, No. 5. pp. 557-568.
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