What proportion of congenital abnormalities can be prevented?

E. Czeizel, Zsolt Intôdy, Bernadette Modell

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Objective - To estimate the proportion of preventable congenital abnormalities in Hungary. Design - Analysis of available Hungarian databases and of the effectiveness of primary, secondary, and tertiary preventive methods. Setting - Databases of ad hoc epidemiological studies and of the Hungarian congenital abnormality registry. Main outcome measures - Prevalence at birth and prevalence after prevention in 73 congenital abnormality types or groups. Results - Preventive methods are available for 51 (70%) of the 73 congenital abnormality types or groups evaluated. The birth prevalence of all congenital abnormalities could be reduced from 65 to 26 per 1000; thus 39 per 1000 (60%) are preventable. Without congenital dislocation of the hip, which is unusually common in Hungary, the preventable proportion of congenital abnormalities is 52%. Conclusion - Many congenital abnormalities can be prevented, but as they do not represent a single pathological category there is no single strategy for their prevention.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalBritish Medical Journal
Volume306
Issue number6876
Publication statusPublished - Feb 20 1993

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Hungary
Parturition
Databases
Congenital Hip Dislocation
Registries
Epidemiologic Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

What proportion of congenital abnormalities can be prevented? / Czeizel, E.; Intôdy, Zsolt; Modell, Bernadette.

In: British Medical Journal, Vol. 306, No. 6876, 20.02.1993, p. 499-503.

Research output: Contribution to journalArticle

Czeizel, E, Intôdy, Z & Modell, B 1993, 'What proportion of congenital abnormalities can be prevented?', British Medical Journal, vol. 306, no. 6876, pp. 499-503.
Czeizel, E. ; Intôdy, Zsolt ; Modell, Bernadette. / What proportion of congenital abnormalities can be prevented?. In: British Medical Journal. 1993 ; Vol. 306, No. 6876. pp. 499-503.
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