Wertheim-mutét: 501 operált méhnyakrákos beteg ötéves túlélési adatai

Translated title of the contribution: Wertheim-operation: 5-year survival of 501 consecutive cases of cervical cancer

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: The purpose of this study was to assess the 5-year survival and morbidity when radical hysterectomy and pelvic lymphadenectomy with pre- and postoperative radiation have been performed for IA2-IIB stage cervical cancer. Study design: During a 10 and a half year period between July, 1990 and December, 2000, 501 consecutive radical hysterectomies with bilateral pelvic lymphadenectomies were performed by the same gynecological surgeon for stage IA2, IB, IIA and IIB carcinoma of the cervix at the I. Department of Obstetrics and Gynecology, Semmelweis University Budapest. The patients were treated by pre- and postoperative irradiation as well. Results: Perioperative complications apart from recurrence were minimal with no long-term morbidity. The absolute 5-year survival rates for the patients in stage IA2, IB1, IB2, IIA and IIB were 94,4%, 90,7%, 84,1%, 71,1% and 55,4%, respectively. The respective 5-year survival rates for patients without or with lymph node metastasis, were 94,5% and 33,3% in stage IB2, 81,7% and 48,7% in stage IIA and 70,2% and 36,5% in stage IIB, respectively. Conclusion: Nerve-sparing radical abdominal hysterectomy with pelvic lymph node dissection and pre- and postoperative irradiation remains the treatment of choice for most patients with early-stage and even in IIB-stage cervical cancer. The radicality and extent of lymph node dissection and parametrial resection should be individualized and tailored to tumor- and patient-related risk factors.

Original languageHungarian
Pages (from-to)537-545
Number of pages9
JournalOrvosi Hetilap
Volume147
Issue number12
Publication statusPublished - Mar 26 2006

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Uterine Cervical Neoplasms
Lymph Node Excision
Hysterectomy
Survival
Survival Rate
Morbidity
Hospital Obstetrics and Gynecology Department
Gynecology
Cervix Uteri
Lymph Nodes
Radiation
Neoplasm Metastasis
Carcinoma
Recurrence
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wertheim-mutét : 501 operált méhnyakrákos beteg ötéves túlélési adatai. / Papp, Zoltán; Csapó, Zsolt; Mayer, Árpád; Hupuczi, Petronella.

In: Orvosi Hetilap, Vol. 147, No. 12, 26.03.2006, p. 537-545.

Research output: Contribution to journalArticle

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title = "Wertheim-mut{\'e}t: 501 oper{\'a}lt m{\'e}hnyakr{\'a}kos beteg {\"o}t{\'e}ves t{\'u}l{\'e}l{\'e}si adatai",
abstract = "Objective: The purpose of this study was to assess the 5-year survival and morbidity when radical hysterectomy and pelvic lymphadenectomy with pre- and postoperative radiation have been performed for IA2-IIB stage cervical cancer. Study design: During a 10 and a half year period between July, 1990 and December, 2000, 501 consecutive radical hysterectomies with bilateral pelvic lymphadenectomies were performed by the same gynecological surgeon for stage IA2, IB, IIA and IIB carcinoma of the cervix at the I. Department of Obstetrics and Gynecology, Semmelweis University Budapest. The patients were treated by pre- and postoperative irradiation as well. Results: Perioperative complications apart from recurrence were minimal with no long-term morbidity. The absolute 5-year survival rates for the patients in stage IA2, IB1, IB2, IIA and IIB were 94,4{\%}, 90,7{\%}, 84,1{\%}, 71,1{\%} and 55,4{\%}, respectively. The respective 5-year survival rates for patients without or with lymph node metastasis, were 94,5{\%} and 33,3{\%} in stage IB2, 81,7{\%} and 48,7{\%} in stage IIA and 70,2{\%} and 36,5{\%} in stage IIB, respectively. Conclusion: Nerve-sparing radical abdominal hysterectomy with pelvic lymph node dissection and pre- and postoperative irradiation remains the treatment of choice for most patients with early-stage and even in IIB-stage cervical cancer. The radicality and extent of lymph node dissection and parametrial resection should be individualized and tailored to tumor- and patient-related risk factors.",
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author = "Zolt{\'a}n Papp and Zsolt Csap{\'o} and {\'A}rp{\'a}d Mayer and Petronella Hupuczi",
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AU - Mayer, Árpád

AU - Hupuczi, Petronella

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N2 - Objective: The purpose of this study was to assess the 5-year survival and morbidity when radical hysterectomy and pelvic lymphadenectomy with pre- and postoperative radiation have been performed for IA2-IIB stage cervical cancer. Study design: During a 10 and a half year period between July, 1990 and December, 2000, 501 consecutive radical hysterectomies with bilateral pelvic lymphadenectomies were performed by the same gynecological surgeon for stage IA2, IB, IIA and IIB carcinoma of the cervix at the I. Department of Obstetrics and Gynecology, Semmelweis University Budapest. The patients were treated by pre- and postoperative irradiation as well. Results: Perioperative complications apart from recurrence were minimal with no long-term morbidity. The absolute 5-year survival rates for the patients in stage IA2, IB1, IB2, IIA and IIB were 94,4%, 90,7%, 84,1%, 71,1% and 55,4%, respectively. The respective 5-year survival rates for patients without or with lymph node metastasis, were 94,5% and 33,3% in stage IB2, 81,7% and 48,7% in stage IIA and 70,2% and 36,5% in stage IIB, respectively. Conclusion: Nerve-sparing radical abdominal hysterectomy with pelvic lymph node dissection and pre- and postoperative irradiation remains the treatment of choice for most patients with early-stage and even in IIB-stage cervical cancer. The radicality and extent of lymph node dissection and parametrial resection should be individualized and tailored to tumor- and patient-related risk factors.

AB - Objective: The purpose of this study was to assess the 5-year survival and morbidity when radical hysterectomy and pelvic lymphadenectomy with pre- and postoperative radiation have been performed for IA2-IIB stage cervical cancer. Study design: During a 10 and a half year period between July, 1990 and December, 2000, 501 consecutive radical hysterectomies with bilateral pelvic lymphadenectomies were performed by the same gynecological surgeon for stage IA2, IB, IIA and IIB carcinoma of the cervix at the I. Department of Obstetrics and Gynecology, Semmelweis University Budapest. The patients were treated by pre- and postoperative irradiation as well. Results: Perioperative complications apart from recurrence were minimal with no long-term morbidity. The absolute 5-year survival rates for the patients in stage IA2, IB1, IB2, IIA and IIB were 94,4%, 90,7%, 84,1%, 71,1% and 55,4%, respectively. The respective 5-year survival rates for patients without or with lymph node metastasis, were 94,5% and 33,3% in stage IB2, 81,7% and 48,7% in stage IIA and 70,2% and 36,5% in stage IIB, respectively. Conclusion: Nerve-sparing radical abdominal hysterectomy with pelvic lymph node dissection and pre- and postoperative irradiation remains the treatment of choice for most patients with early-stage and even in IIB-stage cervical cancer. The radicality and extent of lymph node dissection and parametrial resection should be individualized and tailored to tumor- and patient-related risk factors.

KW - 5-year survival

KW - Cervical cancer

KW - Nerve-sparing radical hysterectomy

KW - Pelvic lymphadenectomy

KW - Pre- and post-operative irradiation

KW - Wertheim-operation

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