Were protein internal repeats formed by 'bricolage'?

Giovanni Lavorgna, La'szlo’ Patthy, Edoardo Boncinelli

Research output: Contribution to journalShort survey

23 Citations (Scopus)


Is evolution an engineer, or is it a tinkerer - a 'bricoleur' - building up complex molecules in organisms by increasing and adapting the materials at hand? An analysis of completely sequenced genomes suggests the latter, showing that increasing repetition of modules within the proteins encoded by these genomes is correlated with increasing complexity of the organism.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalTrends in Genetics
Issue number3
Publication statusPublished - Mar 1 2001

ASJC Scopus subject areas

  • Genetics

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