Wegener's granulomatosis presenting as pyoderma gangrenosum

Hajnal Irén Szõcz, Katalin Torma, Edina Petrovicz, Judit Hársing, György Fekete, Sarolta Kárpáti, Attila Horváth

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A 59-year-old male patient developed a necrotizing ulceration on the right shin. Both clinical and histopathologic examinations suggested pyoderma gangrenosum. After temporary improvement of skin symptoms under peroral glucocorticoid treatment, a hemorrhagic-purulent discharge started from the nose, he began to have fever, malaise, cough, and a chest X-ray revealed inflammation in the lung. Cerebral CT and MRI disclosed midline bone loss within the nasal septum and granulomatosus tissue masses protruding into the right orbit. The c-ANCA test was positive, serum IgA was elevated, and he had microhaematuria and proteinuria. In this severe case of Wegener's granulomatosis prolonged methylprednisone and cyclophosphamide treatment was initiated. Both the skin symptoms and the granulomatosus infiltrations resolved.

Original languageEnglish
Pages (from-to)898-902
Number of pages5
JournalInternational journal of dermatology
Issue number11
Publication statusPublished - Nov 1 2003


ASJC Scopus subject areas

  • Dermatology

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