Wall motion changes in myocardial infarction in relation to the time elapsed from symptoms until revascularization

Ildikó Rácz, L. Fülöp, Rudolf Kolozsvári, Gábor T. Szabó, Annamária Bódi, Andrea Péter, Attila Kertész, Ida Hegedüs, I. Édes, L. Balkay, Zsolt Köszegi

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Abstract

OBJECTIVE: Wall motion abnormalities during acute ST-segment elevation myocardial infarction (STEMI) and the improvement after recanalization depend on the conditions of the coronary occlusion.

METHODS: Fifty-seven patients with first-ever STEMI due to one-artery occlusion, treated with primary PCI, were evaluated. Area at risk and left ventricular wall motion abnormalities were localized with coronary angiography and echocardiography and then compared in relation to the time elapsed from the onset of symptoms at the time of infarction and at 3 months. Left ventricular diameters and ejection fractions were evaluated in relation to the ischemic time.

RESULTS: Three hundred forty-one affected left ventricular segments were detected with angiography, while echocardiography showed 206 segments with motion abnormality. No correlation was found between the regional wall motion index in the area at risk and the time elapsed from the beginning of symptoms. However, the improvement in wall motion abnormalities at the follow-up was dependent on the ischemic time (r=-0.29, p

CONCLUSION: Our results first demonstrate in humans that in the early hours from the occlusion of the coronary artery, the extent and severity of the wall motion abnormalities inside the area at risk show large variability without relation to the elapsed time since the onset of symptoms. On the other hand, the results of follow-up echocardiography proved that the wall motion improvement was highly dependent on the ischemic time.

Original languageEnglish
Pages (from-to)363-370
Number of pages8
JournalAnatolian journal of cardiology
Volume15
Issue number5
DOIs
Publication statusPublished - May 1 2015

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Myocardial Infarction
Echocardiography
Coronary Occlusion
Coronary Angiography
Stroke Volume
Infarction
Coronary Vessels
Angiography
Arteries

ASJC Scopus subject areas

  • Medicine(all)

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Wall motion changes in myocardial infarction in relation to the time elapsed from symptoms until revascularization. / Rácz, Ildikó; Fülöp, L.; Kolozsvári, Rudolf; Szabó, Gábor T.; Bódi, Annamária; Péter, Andrea; Kertész, Attila; Hegedüs, Ida; Édes, I.; Balkay, L.; Köszegi, Zsolt.

In: Anatolian journal of cardiology, Vol. 15, No. 5, 01.05.2015, p. 363-370.

Research output: Contribution to journalArticle

Rácz, Ildikó ; Fülöp, L. ; Kolozsvári, Rudolf ; Szabó, Gábor T. ; Bódi, Annamária ; Péter, Andrea ; Kertész, Attila ; Hegedüs, Ida ; Édes, I. ; Balkay, L. ; Köszegi, Zsolt. / Wall motion changes in myocardial infarction in relation to the time elapsed from symptoms until revascularization. In: Anatolian journal of cardiology. 2015 ; Vol. 15, No. 5. pp. 363-370.
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