VIVO and CuII complexation by ligands based on pyridine nitrogen donors

Daniele Sanna, P. Buglyó, Ana Isabel Tomaz, João Costa Pessoa, Slaana Borović, Giovanni Micera, Eugenio Garribba

Research output: Contribution to journalArticle

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Abstract

The binary and ternary systems formed by VIVO and Cu II ions with ligands (L) based on the pyridine ring (1,10-phenanthroline (phen), 2,2′-bipyridine (bpy), 2,2′:6′, 2′′-terpyridine (terpy), 2,2′-bipyrimidine (bpm) and 2,3-bis(2-pyridyl)pyrazine (bpp)) were studied, combining spectroscopic (EPR and UV-vis), pH-potentiometric and computational (DFT calculations) methods. In the systems with VIVO, the formation of mono-chelated complexes with equatorial-equatorial and equatorial-axial (phen, bpy, bpm and bpp) or equatorial-equatorial-equatorial and equatorial-axial-equatorial coordination (terpy) and bis-chelated species with cis-octahedral geometry, with a water or a hydroxido ion in the fourth equatorial position, is demonstrated. Phen, bpy, bpm and bpp form also a dinuclear [(VO)2L2(H 2O)2(OH)2]2+ complex with an anti-coplanar arrangement of the two VIVO ions and a ferromagnetic coupling between the metal ions. Due to the low basicity of the nitrogen donors, the potentially tetradentate 2,2′-bipyrimidine and 2,3-bis(2-pyridyl) pyrazine behave like simple bidentate ligands, and in the ternary systems with 2,2′-bipyridine the expected dinuclear species, in which the former ligands would act as a bridge between the two metal ions using all four nitrogen donors, are not formed. The interaction of phen and CuII-phen complexes with human serum albumin (HSA) was also studied at pH 7.4 by circular dichroism and EPR spectroscopy, the formation of several HSA-Cu II-phen containing species being confirmed and their binding constants determined.

Original languageEnglish
Pages (from-to)12824-12838
Number of pages15
JournalDalton Transactions
Volume41
Issue number41
DOIs
Publication statusPublished - Nov 7 2012

Fingerprint

Complexation
Nitrogen
Ligands
Pyrazines
Ternary systems
Ions
Serum Albumin
Metal ions
Paramagnetic resonance
Alkalinity
Discrete Fourier transforms
pyridine
1,10-phenanthroline
Spectroscopy
Geometry
Water

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Sanna, D., Buglyó, P., Tomaz, A. I., Pessoa, J. C., Borović, S., Micera, G., & Garribba, E. (2012). VIVO and CuII complexation by ligands based on pyridine nitrogen donors. Dalton Transactions, 41(41), 12824-12838. https://doi.org/10.1039/c2dt31109g

VIVO and CuII complexation by ligands based on pyridine nitrogen donors. / Sanna, Daniele; Buglyó, P.; Tomaz, Ana Isabel; Pessoa, João Costa; Borović, Slaana; Micera, Giovanni; Garribba, Eugenio.

In: Dalton Transactions, Vol. 41, No. 41, 07.11.2012, p. 12824-12838.

Research output: Contribution to journalArticle

Sanna, D, Buglyó, P, Tomaz, AI, Pessoa, JC, Borović, S, Micera, G & Garribba, E 2012, 'VIVO and CuII complexation by ligands based on pyridine nitrogen donors', Dalton Transactions, vol. 41, no. 41, pp. 12824-12838. https://doi.org/10.1039/c2dt31109g
Sanna D, Buglyó P, Tomaz AI, Pessoa JC, Borović S, Micera G et al. VIVO and CuII complexation by ligands based on pyridine nitrogen donors. Dalton Transactions. 2012 Nov 7;41(41):12824-12838. https://doi.org/10.1039/c2dt31109g
Sanna, Daniele ; Buglyó, P. ; Tomaz, Ana Isabel ; Pessoa, João Costa ; Borović, Slaana ; Micera, Giovanni ; Garribba, Eugenio. / VIVO and CuII complexation by ligands based on pyridine nitrogen donors. In: Dalton Transactions. 2012 ; Vol. 41, No. 41. pp. 12824-12838.
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