Volume dependence of airway and tissue impedances in mice

Peter D. Sly, Rachel A. Collins, Cindy Thamrin, Debra J. Turner, Z. Hantos

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

We measured respiratory input impedance (1-25 Hz) in mice and obtained parameters for airway and tissue mechanics by model fitting. Lung volume was varied by inflating to airway opening pressure (Pao) between 0 and 20 cmH2O. The expected pattern of changes in respiratory mechanics with increasing lung volume was seen: a progressive fall in airway resistance and increases in the coefficients of tissue damping and elastance. A surprising pattern was seen in hysteresivity (η), with a plateau at low lung volumes (Pao <10 cmH2O), a sharp fall occurring between 10 and 15 cmH2O, and η approaching a second (lower) plateau at higher lung volumes. Studies designed to elucidate the mechanism(s) behind this behavior revealed that this was not due to chest wall properties, differences in volume history at low lung volume, time dependence of volume recruitment, or surface-acting forces. Our data are consistent with the notion that at low lung volumes the mechanics of the tissue matrix determine η, whereas at high lung volumes the properties of individual fibers (collagen) become more important.

Original languageEnglish
Pages (from-to)1460-1466
Number of pages7
JournalJournal of Applied Physiology
Volume94
Issue number4
Publication statusPublished - Apr 1 2003

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Electric Impedance
Lung
Mechanics
Respiratory Mechanics
Airway Resistance
Thoracic Wall
Collagen
History
Pressure

Keywords

  • Hysteresivity
  • Respiratory mechanics

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Sly, P. D., Collins, R. A., Thamrin, C., Turner, D. J., & Hantos, Z. (2003). Volume dependence of airway and tissue impedances in mice. Journal of Applied Physiology, 94(4), 1460-1466.

Volume dependence of airway and tissue impedances in mice. / Sly, Peter D.; Collins, Rachel A.; Thamrin, Cindy; Turner, Debra J.; Hantos, Z.

In: Journal of Applied Physiology, Vol. 94, No. 4, 01.04.2003, p. 1460-1466.

Research output: Contribution to journalArticle

Sly, PD, Collins, RA, Thamrin, C, Turner, DJ & Hantos, Z 2003, 'Volume dependence of airway and tissue impedances in mice', Journal of Applied Physiology, vol. 94, no. 4, pp. 1460-1466.
Sly PD, Collins RA, Thamrin C, Turner DJ, Hantos Z. Volume dependence of airway and tissue impedances in mice. Journal of Applied Physiology. 2003 Apr 1;94(4):1460-1466.
Sly, Peter D. ; Collins, Rachel A. ; Thamrin, Cindy ; Turner, Debra J. ; Hantos, Z. / Volume dependence of airway and tissue impedances in mice. In: Journal of Applied Physiology. 2003 ; Vol. 94, No. 4. pp. 1460-1466.
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