Volume change of double cross-linked poly(aspartic acid) hydrogels induced by cleavage of one of the crosslinks

Miklos Zrinyi, Tamas Gyenes, David Juriga, Ji Heung Kim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In the present paper we report for the first time the development of redox-responsive biocompatible polymer gels. Double cross-linked poly(aspartic acid) hydrogels were prepared using two different cross-linking agents simultaneously. One of the cross-linkers was diaminobutane (DAB), the other cystamine (CYS). The relative amounts of DAB and CYS molecules were varied over a wide range while the total amount of cross-linker molecules (DAB + CYS) was kept constant. DAB provides stable cross-links, whereas CYS contains disulfide bonds, which can be broken by reduction. The cleavage of disulfide cross-links results in enhanced swelling and a significant decrease in the elastic modulus of the gels. These novel types of stimuli-responsive gels are promising candidates for new swelling controlled release matrices.

Original languageEnglish
Pages (from-to)5122-5131
Number of pages10
JournalActa Biomaterialia
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 1 2013

Keywords

  • Double cross-linked gel
  • Hydrogels
  • Poly(aspartic acid)
  • Polysuccinimide
  • Stimuli-responsive gels

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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