Volatile glycosides from the leaves of Morus alba with a potential contribution to the complex anti-diabetic activity

Attila Hunyadi, Ibolya Herke, Katalin Veres, Anna Erdei, A. Simon, Gábor Tóth

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The leaves and root bark of Morus alba, the white mulberry tree, are well-known traditional medicines for the treatment of type II diabetes. Several different types of constituents have been suggested to be responsible for the anti-diabetic activity of mulberry drugs, such as iminosugars, flavonoids and other phenolic compounds, glycopeptides and ecdysteroids. Our group recently suggested that a volatile-oil like fraction of the hot water extract of M. alba leaves, containing several phenyl-propane derivatives, can increase the glucose consumption of adipocytes. Here we report the isolation of three glycosylated volatile constituents from mulberry leaves, two megastigmane derivatives along with the β-D-glucoside of eugenol. Furthermore, a commercially available mixture of probiotic bacteria was assessed to study the effect of the intestinal flora on the megastigmane derivatives. Significant amounts of the aglycons of both compounds were liberated, suggesting that these compounds can be metabolized in the large intestines and absorbed without the sugar moiety after the consumption of a traditional mulberry tea. Based on literature data, both the glycosides and their aglycons have a potential contribution to the beneficial effects of mulberry leaves in type 2 diabetes.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalNatural Product Communications
Volume9
Issue number2
Publication statusPublished - 2014

Fingerprint

Morus
Morus alba
mulberries
Glycosides
glycosides
norisoprenoids
chemical derivatives
noninsulin-dependent diabetes mellitus
leaves
glycopeptides
Type 2 Diabetes Mellitus
propane
eugenol
ecdysteroids
large intestine
traditional medicine
adipocytes
intestinal microorganisms
tea
probiotics

Keywords

  • Anti-diabetic
  • GC-MS
  • Megastigmane glycoside
  • Morus alba
  • Mulberry leaves
  • NIDDM
  • Phenyl-propane
  • Type 2 diabetes

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Complementary and alternative medicine
  • Plant Science

Cite this

Volatile glycosides from the leaves of Morus alba with a potential contribution to the complex anti-diabetic activity. / Hunyadi, Attila; Herke, Ibolya; Veres, Katalin; Erdei, Anna; Simon, A.; Tóth, Gábor.

In: Natural Product Communications, Vol. 9, No. 2, 2014, p. 145-147.

Research output: Contribution to journalArticle

Hunyadi, Attila ; Herke, Ibolya ; Veres, Katalin ; Erdei, Anna ; Simon, A. ; Tóth, Gábor. / Volatile glycosides from the leaves of Morus alba with a potential contribution to the complex anti-diabetic activity. In: Natural Product Communications. 2014 ; Vol. 9, No. 2. pp. 145-147.
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