Vitiligo and malignant melanoma

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Recent evidence seems to indicate that vitiligo, often a skin marker of internal disease, might belong to the autoimmune diseases. A high proportion of vitiligo patients have antibodies against thyroglobulin, gastric parietal cells and melanin. The coexistence of vitiligo and melanoma is rare. Six cases have been reported. In addition, a case of vitiligo and buccal cancer is described. Widespread vitiligo appeared in the course of irradiation of the tumor. It is suggested that the destruction of tumor cells initiates an antigen antibody reaction, responsible for the outbreak of vitiligo. There seems to be a firm relation between vitiligo and melanoma, the expression of induced autoimmunity.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
Issue number4
Publication statusPublished - Dec 1 1975


ASJC Scopus subject areas

  • Cancer Research

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