Vitamin K epoxide reductase complex 1 (VKORC1) haplotypes in healthy Hungarian and Roma population samples

Csilia Sipeky, Veronika Csongei, Luca Jaromi, Eniko Safrany, Noemi Polgar, Lilla Lakner, Melinda Szabol, Istvan Takacs, Bela Melegh

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Abstract

The aim of this work was to determine the VKORC1 haplotype profile in healthy Hungarian and Roma population samples, and to compare our data with other selected populations. Using haplotype tagging SNPs (G-1639A, G9041A and C6009T), we characterized Hungarian (n=510) and Roma (n= 451) population samples with regard to VKORC1*1, *2, *3 and *4 haplotypes. In the Hungarian samples, the VKORC1*1, *2, *3 and *4 haplotypes accounted for 3, 39, 37 and 21%, respectively and by contrast, in the Roma population samples the VKPORC1 variants were 5, 30, 46 and 19%, respectively. Comparing the genotypes of Roma and Hungariuan populations, difference was found in the *2/*2 (6.87 va 13.5%), *2/*4 (13.9 vs 19.2%) abd *3*3 (21.9 va 13.7%) VKORC1 haplotype combinations. Comparing each group with the others, and our data with findings published previously by other groups, the VKORC1 genetic profile in Hungarians was more similar to European Caucasians and Americans with European descent than to Roma samples. Clear differences could be detected between Roma versus Hungarians and European or American Caucasians: the Roma population had only mimor similarities with data from India.

Original languageEnglish
Pages (from-to)1026-1032
Number of pages7
JournalPharmacogenomics
Volume10
Issue number6
DOIs
Publication statusPublished - Aug 27 2009

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Keywords

  • Anticoagulants
  • Haplotype profile
  • Hungarian
  • Roma
  • VKORC1
  • Warfarin

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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