Vitamin E, lipid profile and peroxidation in hemodialysis patients

F. Galli, Z. Varga, J. Balla, B. Ferraro, F. Canestrari, A. Floridi, G. Kakuk, U. Buoncristiani

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Background. Hypertriglyceridemia, lipid peroxidation, and abnormalities of the plasma fatty acid (PUFA) profile may be important risk factors for the atherosclerotic cardiovascular disease in hemodialysis (HD) patients. Methods. We investigated how these factors are affected by vitamin E supplementation carried out by oral administration (clinical study 1) and dialysis with vitamin E-modified dialyzers (clinical study 2). Results. In the HD patients, conditions of relative vitamin E deficiency were observed [lowered vitamin E/triglyceride (TG) ratio] in the presence of high levels of thiobarbituric acid reactants (TBARs) and decreased levels of the polyunsaturated fraction of PUFAs paired with an increased amount of monounsaturated ones (MUFA). In both studies, vitamin E supplementation significantly increased the levels of vitamin E in the plasma without affecting TG levels and provided a partial correction of TBAR levels. Of note was the relative increase in the PUFA fraction, which gave solid proof of an anti(per)oxidant effect of vitamin E supplementation in HD patients. Vitamin E supplementation was also observed to increase plasma levels of reduced glutathione and NOx (NO2 + NO3). Conclusion. The results suggest that vitamin E supplementation may be an effective accessory therapy that combat oxidative stress-lowering lipid peroxidation in HD patients.

Original languageEnglish
JournalKidney international. Supplement
Volume59
Issue number78
Publication statusPublished - 2001

Fingerprint

Vitamin E
Lipid Peroxidation
Renal Dialysis
Triglycerides
Vitamin E Deficiency
Hypertriglyceridemia
Glutathione
Oral Administration
Dialysis
Oxidative Stress
Cardiovascular Diseases
Fatty Acids
Antioxidants

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Chronic renal failure
  • Hypertriglyceridemia
  • Oral vitamin supplements
  • Plasma fatty acid

ASJC Scopus subject areas

  • Nephrology

Cite this

Galli, F., Varga, Z., Balla, J., Ferraro, B., Canestrari, F., Floridi, A., ... Buoncristiani, U. (2001). Vitamin E, lipid profile and peroxidation in hemodialysis patients. Kidney international. Supplement, 59(78).

Vitamin E, lipid profile and peroxidation in hemodialysis patients. / Galli, F.; Varga, Z.; Balla, J.; Ferraro, B.; Canestrari, F.; Floridi, A.; Kakuk, G.; Buoncristiani, U.

In: Kidney international. Supplement, Vol. 59, No. 78, 2001.

Research output: Contribution to journalArticle

Galli, F, Varga, Z, Balla, J, Ferraro, B, Canestrari, F, Floridi, A, Kakuk, G & Buoncristiani, U 2001, 'Vitamin E, lipid profile and peroxidation in hemodialysis patients', Kidney international. Supplement, vol. 59, no. 78.
Galli, F. ; Varga, Z. ; Balla, J. ; Ferraro, B. ; Canestrari, F. ; Floridi, A. ; Kakuk, G. ; Buoncristiani, U. / Vitamin E, lipid profile and peroxidation in hemodialysis patients. In: Kidney international. Supplement. 2001 ; Vol. 59, No. 78.
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