Vitamin D status in men with psoriatic arthritis: a case-control study

Z. Petho, E. Kulcsar-Jakab, E. Kalina, A. Balogh, A. Pusztai, K. Gulyas, A. Horvath, Z. Szekanecz, H. P. Bhattoa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Summary: We determined hypovitaminosis D prevalence in men with psoriatic arthritis. This is a cross-sectional, analyst blinded, age- and sex-matched, case-control study. Men with psoriatic arthritis have significantly lower 25-hydroxyvitamin D levels. Men with psoriatic arthritis are at increased odds of suffering from hypovitaminosis D. Introduction: Skeletal manifestations as a result of abrupted bone metabolism may be predominant in psoriatic arthritis (PsA). Vitamin D plays a vital role in maintenance of skeletal health and is known to modulate the immune system in various autoimmune diseases including PsA. The aim of the present study was to determine the prevalence of hypovitaminosis D in a treatment naïve, de novo psoriatic arthritis male cohort in a cross-sectional, analyst blinded, age- and sex-matched, case-control study. Methods: 25 hydroxyvitamin D (25OHD), parathyroid (PTH), osteocalcin (OC) and C-terminal telopeptides of type-I collagen (CTx) levels, and lumbar spine and femoral neck bone mineral density were compared between 53 PsA and controls. Results: The prevalence of hypovitaminosis D (25 hydroxyvitamin D (25OHD) levels <75 nmol/L) was 81 and 57 % in the PsA and control groups, respectively. Compared to the healthy controls, 25OHD (67.2 (12–137) nmol/L vs. 51.9 (15–95) nmol/L; p = 0.001) was significantly lower, and osteocalcin (13.6 (5–33) μg/L vs. 18.2 (6–35) μg/L; p = 0.003) and C-terminal telopeptides of type-I collagen (0.20 (0.01–0.71) μg/L vs. 0.28 (0.06–0.69) μg/L; p = 0.008) were significantly higher in the PsA group. A significant association was found between hypovitaminosis D and PsA; the odds for patients with PsA of having hypovitaminosis D was 3.297 (95 % confidence interval 1.372 to 7.922). Conclusion: The results of this study suggest that men with PsA have significantly lower 25-hydroxyvitamin D levels, and furthermore, men with PsA are at statistically significant increased odds of suffering from hypovitaminosis D.

Original languageEnglish
Pages (from-to)1965-1970
Number of pages6
JournalOsteoporosis International
Volume26
Issue number7
DOIs
Publication statusPublished - Jul 30 2015

Keywords

  • Bone markers
  • Bone mineral density
  • Men
  • Psoriatic arthritis
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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