Vitamin D insufficiency in a large MCTD population

Agota Hajas, J. Sándor, Laszlo Csathy, I. Csípő, S. Baráth, G. Paragh, I. Seres, G. Szegedi, Yehuda Shoenfeld, E. Bodolay

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Abstract

Objectives: The aim of the present study was to evaluate the vitamin D status in patients with mixed connective tissue disease (MCTD) and to determine which clinical symptoms, laboratory parameters and endothelial cell markers are associated with low vitamin D levels. Methods: 125 female MCTD patients and 48 age- and sex-matched healthy controls were enrolled in the study. The clinical symptoms, autoantibodies (anti-U1-RNP, anti-cardiolipin - anti-CL and anti-endothelial cell antibody - AECA), serum cytokines (IFN-γ, IL-6, IL-12, IL-23, IL-17 and IL-10), soluble endothelial cell markers (endothelin, thrombomodulin - TM, and von Willebrand factor antigen - vWFAg) and serum lipids (total cholesterol, triglyceride, LDL-C, HDL-C, apolipoprotein A1, and apolipoprotein B) were investigated for an association with vitamin D levels by univariate and multivariate statistical analyses. Results: The mean vitamin D levels were significantly lower in MCTD patients, as compared with the control group (26.16 ± 13.50. ng/ml vs. 34.92 ± 9.64. ng/ml; p <0.001). In laboratory parameters, vitamin D levels were inversely associated with serum IL-6 (p <0.001), IL-23 (p = 0.011), IL-10 (p = 0.033) cytokine levels, TM (p = 0.001) and endothelin (p = 0.033) levels. Low vitamin D levels were also significantly associated with carotid artery intima media thickness (p <0.001), fibrinogen (p = 0.010), total cholesterol (p = 0.042) and ApoA1 (p = 0.004) levels. Among the clinical symptoms, the cardiovascular involvement showed an inverse correlation with vitamin D status in MCTD (p <0.001). Conclusions: The prevalence of vitamin D insufficiency is high in patients with MCTD. We assume that vitamin D insufficiency along with inflammatory parameters and lipid abnormalities may provoke cardiovascular events.

Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalAutoimmunity Reviews
Volume10
Issue number6
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Mixed Connective Tissue Disease
Vitamin D
Population
Interleukin-23
Endothelins
Interleukin-10
Interleukin-6
Endothelial Cells
Serum
Cytokines
Lipids
Thrombomodulin
Carotid Intima-Media Thickness
Cardiolipins
Interleukin-17
Apolipoprotein A-I
von Willebrand Factor
Apolipoproteins B
Interleukin-12
Carotid Arteries

Keywords

  • Autoantibodies
  • Cardiovascular diseases
  • Inflammatory cytokines
  • Mixed connective tissue disease
  • Vitamin D

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Vitamin D insufficiency in a large MCTD population. / Hajas, Agota; Sándor, J.; Csathy, Laszlo; Csípő, I.; Baráth, S.; Paragh, G.; Seres, I.; Szegedi, G.; Shoenfeld, Yehuda; Bodolay, E.

In: Autoimmunity Reviews, Vol. 10, No. 6, 04.2011, p. 317-324.

Research output: Contribution to journalArticle

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abstract = "Objectives: The aim of the present study was to evaluate the vitamin D status in patients with mixed connective tissue disease (MCTD) and to determine which clinical symptoms, laboratory parameters and endothelial cell markers are associated with low vitamin D levels. Methods: 125 female MCTD patients and 48 age- and sex-matched healthy controls were enrolled in the study. The clinical symptoms, autoantibodies (anti-U1-RNP, anti-cardiolipin - anti-CL and anti-endothelial cell antibody - AECA), serum cytokines (IFN-γ, IL-6, IL-12, IL-23, IL-17 and IL-10), soluble endothelial cell markers (endothelin, thrombomodulin - TM, and von Willebrand factor antigen - vWFAg) and serum lipids (total cholesterol, triglyceride, LDL-C, HDL-C, apolipoprotein A1, and apolipoprotein B) were investigated for an association with vitamin D levels by univariate and multivariate statistical analyses. Results: The mean vitamin D levels were significantly lower in MCTD patients, as compared with the control group (26.16 ± 13.50. ng/ml vs. 34.92 ± 9.64. ng/ml; p <0.001). In laboratory parameters, vitamin D levels were inversely associated with serum IL-6 (p <0.001), IL-23 (p = 0.011), IL-10 (p = 0.033) cytokine levels, TM (p = 0.001) and endothelin (p = 0.033) levels. Low vitamin D levels were also significantly associated with carotid artery intima media thickness (p <0.001), fibrinogen (p = 0.010), total cholesterol (p = 0.042) and ApoA1 (p = 0.004) levels. Among the clinical symptoms, the cardiovascular involvement showed an inverse correlation with vitamin D status in MCTD (p <0.001). Conclusions: The prevalence of vitamin D insufficiency is high in patients with MCTD. We assume that vitamin D insufficiency along with inflammatory parameters and lipid abnormalities may provoke cardiovascular events.",
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AU - Hajas, Agota

AU - Sándor, J.

AU - Csathy, Laszlo

AU - Csípő, I.

AU - Baráth, S.

AU - Paragh, G.

AU - Seres, I.

AU - Szegedi, G.

AU - Shoenfeld, Yehuda

AU - Bodolay, E.

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N2 - Objectives: The aim of the present study was to evaluate the vitamin D status in patients with mixed connective tissue disease (MCTD) and to determine which clinical symptoms, laboratory parameters and endothelial cell markers are associated with low vitamin D levels. Methods: 125 female MCTD patients and 48 age- and sex-matched healthy controls were enrolled in the study. The clinical symptoms, autoantibodies (anti-U1-RNP, anti-cardiolipin - anti-CL and anti-endothelial cell antibody - AECA), serum cytokines (IFN-γ, IL-6, IL-12, IL-23, IL-17 and IL-10), soluble endothelial cell markers (endothelin, thrombomodulin - TM, and von Willebrand factor antigen - vWFAg) and serum lipids (total cholesterol, triglyceride, LDL-C, HDL-C, apolipoprotein A1, and apolipoprotein B) were investigated for an association with vitamin D levels by univariate and multivariate statistical analyses. Results: The mean vitamin D levels were significantly lower in MCTD patients, as compared with the control group (26.16 ± 13.50. ng/ml vs. 34.92 ± 9.64. ng/ml; p <0.001). In laboratory parameters, vitamin D levels were inversely associated with serum IL-6 (p <0.001), IL-23 (p = 0.011), IL-10 (p = 0.033) cytokine levels, TM (p = 0.001) and endothelin (p = 0.033) levels. Low vitamin D levels were also significantly associated with carotid artery intima media thickness (p <0.001), fibrinogen (p = 0.010), total cholesterol (p = 0.042) and ApoA1 (p = 0.004) levels. Among the clinical symptoms, the cardiovascular involvement showed an inverse correlation with vitamin D status in MCTD (p <0.001). Conclusions: The prevalence of vitamin D insufficiency is high in patients with MCTD. We assume that vitamin D insufficiency along with inflammatory parameters and lipid abnormalities may provoke cardiovascular events.

AB - Objectives: The aim of the present study was to evaluate the vitamin D status in patients with mixed connective tissue disease (MCTD) and to determine which clinical symptoms, laboratory parameters and endothelial cell markers are associated with low vitamin D levels. Methods: 125 female MCTD patients and 48 age- and sex-matched healthy controls were enrolled in the study. The clinical symptoms, autoantibodies (anti-U1-RNP, anti-cardiolipin - anti-CL and anti-endothelial cell antibody - AECA), serum cytokines (IFN-γ, IL-6, IL-12, IL-23, IL-17 and IL-10), soluble endothelial cell markers (endothelin, thrombomodulin - TM, and von Willebrand factor antigen - vWFAg) and serum lipids (total cholesterol, triglyceride, LDL-C, HDL-C, apolipoprotein A1, and apolipoprotein B) were investigated for an association with vitamin D levels by univariate and multivariate statistical analyses. Results: The mean vitamin D levels were significantly lower in MCTD patients, as compared with the control group (26.16 ± 13.50. ng/ml vs. 34.92 ± 9.64. ng/ml; p <0.001). In laboratory parameters, vitamin D levels were inversely associated with serum IL-6 (p <0.001), IL-23 (p = 0.011), IL-10 (p = 0.033) cytokine levels, TM (p = 0.001) and endothelin (p = 0.033) levels. Low vitamin D levels were also significantly associated with carotid artery intima media thickness (p <0.001), fibrinogen (p = 0.010), total cholesterol (p = 0.042) and ApoA1 (p = 0.004) levels. Among the clinical symptoms, the cardiovascular involvement showed an inverse correlation with vitamin D status in MCTD (p <0.001). Conclusions: The prevalence of vitamin D insufficiency is high in patients with MCTD. We assume that vitamin D insufficiency along with inflammatory parameters and lipid abnormalities may provoke cardiovascular events.

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KW - Inflammatory cytokines

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