Vitamin D deficiency is associated with impaired disease control in asthma-COPD overlap syndrome patients

Balázs Ödler, István Ivancsó, Vivien Somogyi, Kálmán Benke, Lilla Tamási, Gabriella Gálffy, Balázs Szalay, Veronika Müller

Research output: Contribution to journalArticle

5 Citations (Scopus)


Introduction: The association between vitamin D and clinical parameters in obstructive lung diseases (OLDs), including COPD and bronchial asthma, was previously investigated. As asthma-COPD overlap syndrome (ACOS) is a new clinical entity, the prevalence of vitamin D levels in ACOS is unknown. Aim: Our aim was to assess the levels of circulating vitamin D (25-hydroxyvitamin D [25(OH)D]) in different OLDs, including ACOS patients, and its correlation with clinical parameters. Methods: A total of 106 men and women (control, n=21; asthma, n=44; COPD, n=21; and ACOS, n=20) were involved in the study. All patients underwent detailed clinical examinations; disease control and severity was assessed by disease-specific questionnaires (COPD assessment test, asthma control test, and modified Medical Research Council); furthermore, 25(OH)D levels were measured in all patients. Results: The 25(OH)D level was significantly lower in ACOS and COPD groups compared to asthma group (16.86+1.79 ng/mL and 14.27+1.88 ng/mL vs 25.66+1.91 ng/mL). A positive correlation was found between 25(OH)D level and forced expiratory volume in 1 second (r=0.4433; P<0.0001), forced vital capacity (FVC) (r=0.3741; P=0.0004), forced expiratory flow between 25% and 75% of FVC (r=0.4179; P<0.0001), and peak expiratory flow (r=0.4846; P<0.0001) in OLD patient groups. Asthma control test total scores and the 25(OH)D level showed a positive correlation in the ACOS (r=0.4761; P=0.0339) but not in the asthma group. Higher COPD assessment test total scores correlated with decreased 25(OH)D in ACOS (r=-0.4446; P=0.0495); however, this was not observed in the COPD group. Conclusion: Vitamin D deficiency is present in ACOS patients and circulating 25(OH)D level may affect disease control and severity.

Original languageEnglish
Pages (from-to)2017-2025
Number of pages9
JournalInternational Journal of COPD
Issue number1
Publication statusPublished - Sep 24 2015


  • ACOS
  • CAT
  • Obstructive lung disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health

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