Vitamin D deficiency and androgen excess result eutrophic remodeling and reduced myogenic adaptation in small cerebral arterioles in female rats

Leila Hadjadj, Éva Pál, Anna Monori-Kiss, Réka Eszter Sziva, Ágnes Korsós-Novák, Eszter Mária Horváth, Rita Benkő, A. Magyar, Péter Magyar, Z. Benyó, G. Nádasy, S. Várbíró

Research output: Contribution to journalArticle

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Abstract

Vitamin D (vitD) insufficiency affects 1 billion people worldwide. Androgen excess (AE) occurs in 8% of fertile females. There are few data about the combined effect of vitD deficiency and AE on the early biomechanical changes of cerebral arterioles in fertile-aged female. Forty-six adolescent female Wistar rats (21–28 day-old, weighing 90–110 g) were grouped randomly in four groups: vitD supplemented groups with and without transdermal testosterone (T) treatment, as well as vitD deficient groups also with and without transdermal T (n = 11 or 12, in all cases). After 8 weeks of treatment, anterior cerebral arterioles (in vivo diameter of 90–130 µm) were obtained and cylindrical segments were examined by pressure arteriography. Myogenic tone, tangential stress and incremental elastic moduli were computed and statistically analyzed. Elastic density was studied on resorcin-fuchsin-stained histological section. VitD deficiency with T treatment resulted in significantly lower inner radii and higher wall thickness values with reduced tangential stress and increased elastic fiber density. VitD deficiency reduced myogenic tone at higher intraluminar pressures (>110 mmHg). Our conclusion is that plasma vitD level is an important factor in the control of myogenic tone in cerebral resistance arteries. AE and vitD deficiency acting parallel induce remodeling of their wall.

Original languageEnglish
JournalGynecological Endocrinology
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Vitamin D Deficiency
Arterioles
Vitamin D
Androgens
Rosaniline Dyes
Pressure
Cerebral Arteries
Elastic Tissue
Elastic Modulus
Testosterone
Wistar Rats
Angiography
Therapeutics

Keywords

  • Androgen excess
  • anterior cerebral artery
  • cerebrovascular disease
  • rodent model
  • vitD deficiency

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynaecology

Cite this

Vitamin D deficiency and androgen excess result eutrophic remodeling and reduced myogenic adaptation in small cerebral arterioles in female rats. / Hadjadj, Leila; Pál, Éva; Monori-Kiss, Anna; Sziva, Réka Eszter; Korsós-Novák, Ágnes; Mária Horváth, Eszter; Benkő, Rita; Magyar, A.; Magyar, Péter; Benyó, Z.; Nádasy, G.; Várbíró, S.

In: Gynecological Endocrinology, 01.01.2019.

Research output: Contribution to journalArticle

Hadjadj, Leila ; Pál, Éva ; Monori-Kiss, Anna ; Sziva, Réka Eszter ; Korsós-Novák, Ágnes ; Mária Horváth, Eszter ; Benkő, Rita ; Magyar, A. ; Magyar, Péter ; Benyó, Z. ; Nádasy, G. ; Várbíró, S. / Vitamin D deficiency and androgen excess result eutrophic remodeling and reduced myogenic adaptation in small cerebral arterioles in female rats. In: Gynecological Endocrinology. 2019.
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AU - Pál, Éva

AU - Monori-Kiss, Anna

AU - Sziva, Réka Eszter

AU - Korsós-Novák, Ágnes

AU - Mária Horváth, Eszter

AU - Benkő, Rita

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AU - Magyar, Péter

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AU - Nádasy, G.

AU - Várbíró, S.

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