Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity

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Abstract

Objective: We studied the significance of BsmI restriction enzyme polymorphism of the vitamin D receptor (VDR) gene and the XbaI and PvuII polymorphisms of the estrogen receptor (ER) gene in patients with type 2 diabetes (n = 49), android type obesity with normal carbohydrate metabolism (n = 29) and healthy controls (n = 138). Methods: The distribution of genotypes in the study groups, as well as their relationship to fasting and 1 h postprandial serum C-peptide levels were analyzed. Results: Postprandial serum C-peptide levels of BB genotypes were significantly higher in the diabetes and obese groups (6.18 ± 5.09 ng/ml) compared with other genotypes (2.71 ± 2.45 vs. 1.72 ± 1.97 ng/ml, respectively, P = 0.05). Among patients with type 2 diabetes and obese subjects, the XX allelic variant of the ER gene was more frequent (P = 0.00015). Postprandial C-peptide levels of subjects exhibiting XX genotype were significantly lower compared with those with Xx genotype (1.67 ± 2.16 vs. 3.8 ± 3.72 ng/ml, P = 0.021). The BBXx allelic combination of the VDR/ER receptor genes was less frequent in diabetic patients than in healthy subjects or in obese patients. The BBXx genotype was associated with significantly elevated postprandial C-peptide levels in all subjects compared with other combinations (9.65 ± 3.14 vs. 1.35 ± 2.82 ng/ml, P = 0.003). No difference was found in the distribution of the Pvull polymorphism of the ER gene or in the association with the C-peptide levels among study groups. Conclusion: Polymorphisms of the VDR/ER receptor genes might play a role in the pathogenesis of type 2 diabetes by influencing the secretory capacity of β-cells.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
JournalEuropean Journal of Endocrinology
Volume144
Issue number4
Publication statusPublished - 2001

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Calcitriol Receptors
C-Peptide
Estrogen Receptors
Type 2 Diabetes Mellitus
Obesity
Genotype
Genes
Carbohydrate Metabolism
Serum
Fasting
Healthy Volunteers
Enzymes

ASJC Scopus subject areas

  • Endocrinology

Cite this

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title = "Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity",
abstract = "Objective: We studied the significance of BsmI restriction enzyme polymorphism of the vitamin D receptor (VDR) gene and the XbaI and PvuII polymorphisms of the estrogen receptor (ER) gene in patients with type 2 diabetes (n = 49), android type obesity with normal carbohydrate metabolism (n = 29) and healthy controls (n = 138). Methods: The distribution of genotypes in the study groups, as well as their relationship to fasting and 1 h postprandial serum C-peptide levels were analyzed. Results: Postprandial serum C-peptide levels of BB genotypes were significantly higher in the diabetes and obese groups (6.18 ± 5.09 ng/ml) compared with other genotypes (2.71 ± 2.45 vs. 1.72 ± 1.97 ng/ml, respectively, P = 0.05). Among patients with type 2 diabetes and obese subjects, the XX allelic variant of the ER gene was more frequent (P = 0.00015). Postprandial C-peptide levels of subjects exhibiting XX genotype were significantly lower compared with those with Xx genotype (1.67 ± 2.16 vs. 3.8 ± 3.72 ng/ml, P = 0.021). The BBXx allelic combination of the VDR/ER receptor genes was less frequent in diabetic patients than in healthy subjects or in obese patients. The BBXx genotype was associated with significantly elevated postprandial C-peptide levels in all subjects compared with other combinations (9.65 ± 3.14 vs. 1.35 ± 2.82 ng/ml, P = 0.003). No difference was found in the distribution of the Pvull polymorphism of the ER gene or in the association with the C-peptide levels among study groups. Conclusion: Polymorphisms of the VDR/ER receptor genes might play a role in the pathogenesis of type 2 diabetes by influencing the secretory capacity of β-cells.",
author = "G. Speer and K. Cseh and G. Winkler and P. Vargha and E. Braun and I. Tak{\'a}cs and P. Lakatos",
year = "2001",
language = "English",
volume = "144",
pages = "385--389",
journal = "European Journal of Endocrinology",
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TY - JOUR

T1 - Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity

AU - Speer, G.

AU - Cseh, K.

AU - Winkler, G.

AU - Vargha, P.

AU - Braun, E.

AU - Takács, I.

AU - Lakatos, P.

PY - 2001

Y1 - 2001

N2 - Objective: We studied the significance of BsmI restriction enzyme polymorphism of the vitamin D receptor (VDR) gene and the XbaI and PvuII polymorphisms of the estrogen receptor (ER) gene in patients with type 2 diabetes (n = 49), android type obesity with normal carbohydrate metabolism (n = 29) and healthy controls (n = 138). Methods: The distribution of genotypes in the study groups, as well as their relationship to fasting and 1 h postprandial serum C-peptide levels were analyzed. Results: Postprandial serum C-peptide levels of BB genotypes were significantly higher in the diabetes and obese groups (6.18 ± 5.09 ng/ml) compared with other genotypes (2.71 ± 2.45 vs. 1.72 ± 1.97 ng/ml, respectively, P = 0.05). Among patients with type 2 diabetes and obese subjects, the XX allelic variant of the ER gene was more frequent (P = 0.00015). Postprandial C-peptide levels of subjects exhibiting XX genotype were significantly lower compared with those with Xx genotype (1.67 ± 2.16 vs. 3.8 ± 3.72 ng/ml, P = 0.021). The BBXx allelic combination of the VDR/ER receptor genes was less frequent in diabetic patients than in healthy subjects or in obese patients. The BBXx genotype was associated with significantly elevated postprandial C-peptide levels in all subjects compared with other combinations (9.65 ± 3.14 vs. 1.35 ± 2.82 ng/ml, P = 0.003). No difference was found in the distribution of the Pvull polymorphism of the ER gene or in the association with the C-peptide levels among study groups. Conclusion: Polymorphisms of the VDR/ER receptor genes might play a role in the pathogenesis of type 2 diabetes by influencing the secretory capacity of β-cells.

AB - Objective: We studied the significance of BsmI restriction enzyme polymorphism of the vitamin D receptor (VDR) gene and the XbaI and PvuII polymorphisms of the estrogen receptor (ER) gene in patients with type 2 diabetes (n = 49), android type obesity with normal carbohydrate metabolism (n = 29) and healthy controls (n = 138). Methods: The distribution of genotypes in the study groups, as well as their relationship to fasting and 1 h postprandial serum C-peptide levels were analyzed. Results: Postprandial serum C-peptide levels of BB genotypes were significantly higher in the diabetes and obese groups (6.18 ± 5.09 ng/ml) compared with other genotypes (2.71 ± 2.45 vs. 1.72 ± 1.97 ng/ml, respectively, P = 0.05). Among patients with type 2 diabetes and obese subjects, the XX allelic variant of the ER gene was more frequent (P = 0.00015). Postprandial C-peptide levels of subjects exhibiting XX genotype were significantly lower compared with those with Xx genotype (1.67 ± 2.16 vs. 3.8 ± 3.72 ng/ml, P = 0.021). The BBXx allelic combination of the VDR/ER receptor genes was less frequent in diabetic patients than in healthy subjects or in obese patients. The BBXx genotype was associated with significantly elevated postprandial C-peptide levels in all subjects compared with other combinations (9.65 ± 3.14 vs. 1.35 ± 2.82 ng/ml, P = 0.003). No difference was found in the distribution of the Pvull polymorphism of the ER gene or in the association with the C-peptide levels among study groups. Conclusion: Polymorphisms of the VDR/ER receptor genes might play a role in the pathogenesis of type 2 diabetes by influencing the secretory capacity of β-cells.

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