Vitamin D and autoimmune thyroid diseases

Shaye Kivity, Nancy Agmon-Levin, Michael Zisappl, Yinon Shapira, E. Nagy, K. Dankó, Z. Szekanecz, Pnina Langevitz, Yehuda Shoenfeld

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The role of vitamin D as an immune modulator has been emphasized in recent years, and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus erythematosus. Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. While VDR gene polymorphism was found to associate with autoimmune thyroid diseases (AITDs), few studies examined levels of vitamin D in these patients and those that did yielded conflicting results. We therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy controls. Serum vitamin D (25-OH) levels were measured in 50 patients with AITDs, 42 patients with non-AITDs and 98 healthy subjects, utilizing the LIAISON chemiluminescence immunoassay (DiaSorin, Saluggia, Italy). Vitamin D deficiency was designated at levels lower than 10ng/ml. Antithyroid antibodies, thyroid functions and demographic parameters were evaluated in all patients. The prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals (72% versus 30.6%; P

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalCellular and Molecular Immunology
Volume8
Issue number3
DOIs
Publication statusPublished - May 2011

Fingerprint

Thyroid Diseases
Vitamin D
Autoimmune Diseases
Calcitriol Receptors
Vitamin D Deficiency
Luminescence
Immunoassay
Systemic Lupus Erythematosus
Italy
Genes
Multiple Sclerosis
Healthy Volunteers
Thyroid Gland
Demography
Hormones
Antibodies
Serum

Keywords

  • autoantibodies
  • autoimmune thyroid disease
  • Graves' disease
  • Hashimoto's thyroiditis
  • vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Kivity, S., Agmon-Levin, N., Zisappl, M., Shapira, Y., Nagy, E., Dankó, K., ... Shoenfeld, Y. (2011). Vitamin D and autoimmune thyroid diseases. Cellular and Molecular Immunology, 8(3), 243-247. https://doi.org/10.1038/cmi.2010.73

Vitamin D and autoimmune thyroid diseases. / Kivity, Shaye; Agmon-Levin, Nancy; Zisappl, Michael; Shapira, Yinon; Nagy, E.; Dankó, K.; Szekanecz, Z.; Langevitz, Pnina; Shoenfeld, Yehuda.

In: Cellular and Molecular Immunology, Vol. 8, No. 3, 05.2011, p. 243-247.

Research output: Contribution to journalArticle

Kivity, S, Agmon-Levin, N, Zisappl, M, Shapira, Y, Nagy, E, Dankó, K, Szekanecz, Z, Langevitz, P & Shoenfeld, Y 2011, 'Vitamin D and autoimmune thyroid diseases', Cellular and Molecular Immunology, vol. 8, no. 3, pp. 243-247. https://doi.org/10.1038/cmi.2010.73
Kivity, Shaye ; Agmon-Levin, Nancy ; Zisappl, Michael ; Shapira, Yinon ; Nagy, E. ; Dankó, K. ; Szekanecz, Z. ; Langevitz, Pnina ; Shoenfeld, Yehuda. / Vitamin D and autoimmune thyroid diseases. In: Cellular and Molecular Immunology. 2011 ; Vol. 8, No. 3. pp. 243-247.
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