Visible light induces matrix metalloproteinase-9 expression in rat eye

Andrea M. Papp, Rita Nyilas, Zsuzsanna Szepesi, Magor L. Lorincz, Eszter Takács, István Ábrahám, N. Szilágyi, Júlia Tóth, Péter Medveczky, László Szilágyi, G. Juhász, G. Juhász

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Up-regulation of matrix metalloproteinase-9 (MMP-9, gelatinase B) in the nervous system has been demonstrated when excitotoxicity-induced tissue remodeling and neuronal death occurs. Induction of MMP-9 by a natural stimulus has not been observed yet. Using RT-PCR and gelatin-zymography we demonstrated MMP-9 induction at transcriptional and protein levels in different structures of the rat eye following over-stimulation with white light. MMP-9 elevation occurred in the retina without reduction in photoreceptor number or major anatomical reorganization. A transient decrease in electroretinogram b-wave indicated the functional recovery. Retrobulbar injection of a broad-spectrum MMP-inhibitor GM6001, slowed the recovery rate of b-wave amplitude. Even room-light applied to dark-adapted awake animals induced MMP-9 increase in the retina, which suggests a role for MMP-9 in physiological functional plasticity of the nervous system, such as light adaptation. This is the first demonstration of MMP-9 induction by a sensory stimulus.

Original languageEnglish
Pages (from-to)2224-2233
Number of pages10
JournalJournal of Neurochemistry
Volume103
Issue number6
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Matrix Metalloproteinase 9
Matrix Metalloproteinases
Rats
Light
Neurology
Nervous System
Retina
Ocular Adaptation
Recovery
Neuronal Plasticity
Matrix Metalloproteinase Inhibitors
Gelatin
Plasticity
Animals
Up-Regulation
Demonstrations
Tissue
Polymerase Chain Reaction
Injections
Proteins

Keywords

  • B-wave
  • Electroretinogram
  • Gelatinase B
  • GM6001
  • Light
  • Matrix metalloproteinase-9

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Papp, A. M., Nyilas, R., Szepesi, Z., Lorincz, M. L., Takács, E., Ábrahám, I., ... Juhász, G. (2007). Visible light induces matrix metalloproteinase-9 expression in rat eye. Journal of Neurochemistry, 103(6), 2224-2233. https://doi.org/10.1111/j.1471-4159.2007.04917.x

Visible light induces matrix metalloproteinase-9 expression in rat eye. / Papp, Andrea M.; Nyilas, Rita; Szepesi, Zsuzsanna; Lorincz, Magor L.; Takács, Eszter; Ábrahám, István; Szilágyi, N.; Tóth, Júlia; Medveczky, Péter; Szilágyi, László; Juhász, G.; Juhász, G.

In: Journal of Neurochemistry, Vol. 103, No. 6, 12.2007, p. 2224-2233.

Research output: Contribution to journalArticle

Papp, AM, Nyilas, R, Szepesi, Z, Lorincz, ML, Takács, E, Ábrahám, I, Szilágyi, N, Tóth, J, Medveczky, P, Szilágyi, L, Juhász, G & Juhász, G 2007, 'Visible light induces matrix metalloproteinase-9 expression in rat eye', Journal of Neurochemistry, vol. 103, no. 6, pp. 2224-2233. https://doi.org/10.1111/j.1471-4159.2007.04917.x
Papp AM, Nyilas R, Szepesi Z, Lorincz ML, Takács E, Ábrahám I et al. Visible light induces matrix metalloproteinase-9 expression in rat eye. Journal of Neurochemistry. 2007 Dec;103(6):2224-2233. https://doi.org/10.1111/j.1471-4159.2007.04917.x
Papp, Andrea M. ; Nyilas, Rita ; Szepesi, Zsuzsanna ; Lorincz, Magor L. ; Takács, Eszter ; Ábrahám, István ; Szilágyi, N. ; Tóth, Júlia ; Medveczky, Péter ; Szilágyi, László ; Juhász, G. ; Juhász, G. / Visible light induces matrix metalloproteinase-9 expression in rat eye. In: Journal of Neurochemistry. 2007 ; Vol. 103, No. 6. pp. 2224-2233.
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