Visible light induces matrix metalloproteinase-9 expression in rat eye

Andrea M. Papp, Rita Nyilas, Zsuzsanna Szepesi, Magor L. Lorincz, Eszter Takács, István Ábrahám, Nóra Szilágyi, Júlia Tóth, Péter Medveczky, László Szilágyi, Gábor Juhász, Gábor Juhász

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7 Citations (Scopus)

Abstract

Up-regulation of matrix metalloproteinase-9 (MMP-9, gelatinase B) in the nervous system has been demonstrated when excitotoxicity-induced tissue remodeling and neuronal death occurs. Induction of MMP-9 by a natural stimulus has not been observed yet. Using RT-PCR and gelatin-zymography we demonstrated MMP-9 induction at transcriptional and protein levels in different structures of the rat eye following over-stimulation with white light. MMP-9 elevation occurred in the retina without reduction in photoreceptor number or major anatomical reorganization. A transient decrease in electroretinogram b-wave indicated the functional recovery. Retrobulbar injection of a broad-spectrum MMP-inhibitor GM6001, slowed the recovery rate of b-wave amplitude. Even room-light applied to dark-adapted awake animals induced MMP-9 increase in the retina, which suggests a role for MMP-9 in physiological functional plasticity of the nervous system, such as light adaptation. This is the first demonstration of MMP-9 induction by a sensory stimulus.

Original languageEnglish
Pages (from-to)2224-2233
Number of pages10
JournalJournal of neurochemistry
Volume103
Issue number6
DOIs
Publication statusPublished - Dec 1 2007

Keywords

  • B-wave
  • Electroretinogram
  • GM6001
  • Gelatinase B
  • Light
  • Matrix metalloproteinase-9

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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  • Cite this

    Papp, A. M., Nyilas, R., Szepesi, Z., Lorincz, M. L., Takács, E., Ábrahám, I., Szilágyi, N., Tóth, J., Medveczky, P., Szilágyi, L., Juhász, G., & Juhász, G. (2007). Visible light induces matrix metalloproteinase-9 expression in rat eye. Journal of neurochemistry, 103(6), 2224-2233. https://doi.org/10.1111/j.1471-4159.2007.04917.x