Virus-induced gene silencing of Mlo genes induces powdery mildew resistance in Triticum aestivum

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Powdery mildew is one of the most important cereal diseases worldwide. Genetic analysis has revealed that mutant alleles of the Mlo gene cause broad-spectrum resistance against this pathogen in barley. In this study, the possibility of inducing broad-spectrum powdery mildew resistance against this pathogen by RNAi of the barley Mlo ortholog in wheat was examined using virus-induced gene silencing (VIGS). A clear correlation was found between resistance and accumulation of Mlo-specific siRNAs, raising the possibility of designing powdery mildew resistance in wheat by RNA silencing using both transgenic and non-transgenic approaches.

Original languageEnglish
Pages (from-to)1345-1350
Number of pages6
JournalArchives of virology
Issue number7
Publication statusPublished - Jul 1 2012


ASJC Scopus subject areas

  • Virology

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