Virological risks and benefits of cord blood banking

György Berencsi, Márta Csire, Katalin Szomor, Erzsébet Barcsay, Katalin Ördög, Mária Takács, János Minárovits

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The risks of the reactivation of latently carried maternal viruses during pregnancy and the transfer of primary maternal viral infections to fetus due to the maternal immunomodulation may also affect the safety of the umbilical cord blood banking. Microchymerism, transcytosis, transfer of virus-immunoglobulin complexes and replication of viruses in placental and fetal cells are the mechanisms of the maternal-fetal transfer of viruses. Very few virus harbouring cells in the cord blood preparations might endanger the health of transplant recipients. Very few cells with latent viruses can be amplified and released during the in vitro expansion of the pluripotent umbilical cord blood cell (UCB) populations.

Original languageEnglish
Title of host publicationCord Blood
Subtitle of host publicationBanks and Banking, Ethical Issues and Risks/Benefits
PublisherNova Science Publishers, Inc.
Pages1-57
Number of pages57
ISBN (Print)9781626180727
Publication statusPublished - Dec 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Berencsi, G., Csire, M., Szomor, K., Barcsay, E., Ördög, K., Takács, M., & Minárovits, J. (2013). Virological risks and benefits of cord blood banking. In Cord Blood: Banks and Banking, Ethical Issues and Risks/Benefits (pp. 1-57). Nova Science Publishers, Inc..