Viral silencing suppressors: Tools forged to fine-tune host-pathogen coexistence

Tibor Csorba, Levente Kontra, J. Burgyán

Research output: Contribution to journalArticle

178 Citations (Scopus)

Abstract

RNA silencing is a homology-dependent gene inactivation mechanism that regulates a wide range of biological processes including antiviral defense. To deal with host antiviral responses viruses evolved mechanisms to avoid or counteract this, most notably through expression of viral suppressors of RNA silencing. Besides working as silencing suppressors, these proteins may also fulfill other functions during infection. In many cases the interplay between the suppressor function and other "unrelated" functions remains elusive. We will present host factors implicated in antiviral pathways and summarize the current status of knowledge about the diverse viral suppressors' strategies acting at various steps of antiviral silencing in plants. Besides, we will consider the multi-functionality of these versatile proteins and related biochemical processes in which they may be involved in fine-tuning the plant-virus interaction. Finally, we will present the current applications and discuss perspectives of the use of these proteins in molecular biology and biotechnology.

Original languageEnglish
Pages (from-to)85-103
Number of pages19
JournalVirology
Volume479-480
DOIs
Publication statusPublished - May 1 2015

Fingerprint

Antiviral Agents
RNA Interference
Biochemical Phenomena
Biological Phenomena
Plant Viruses
Proteins
Viral RNA
Gene Silencing
Biotechnology
Molecular Biology
Viruses
Infection

Keywords

  • Antiviral RNA interference
  • Defense
  • Pathogenesis
  • Plants
  • Viral suppressors of silencing
  • Viruses

ASJC Scopus subject areas

  • Virology
  • Medicine(all)

Cite this

Viral silencing suppressors : Tools forged to fine-tune host-pathogen coexistence. / Csorba, Tibor; Kontra, Levente; Burgyán, J.

In: Virology, Vol. 479-480, 01.05.2015, p. 85-103.

Research output: Contribution to journalArticle

Csorba, Tibor ; Kontra, Levente ; Burgyán, J. / Viral silencing suppressors : Tools forged to fine-tune host-pathogen coexistence. In: Virology. 2015 ; Vol. 479-480. pp. 85-103.
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