Viral hit-and-run tumorigenesis

J. Mináróvits, Ferenc Banati, Hans Helmut Niller

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Evaluation of: Stevenson PG, May JS, Connor V, Efstathiou S: Vaccination against a hit-and-run viral cancer. J. Gen. Virol. 91, 2176-2185 (2010). Viral hit-and-run oncogenesis scenarios suggest that transient acquisition of viral genomes can induce a permanent change in the gene expression pattern of the host cell, resulting in malignant conversion. Stevenson et al. developed an in vivo model system based on the introduction of a Cre-recombinase positive murid herpesvirus into genetically engineered mice. They demonstrated that the Cre recombinase could switch on a silent oncogene and inactivate a tumor suppressor gene resulting in sarcomagenesis. However, some of the tumors lacked herpesvirus genomes, suggesting a hit-and-run type oncogenesis. The authors also observed that vaccination could prevent sarcomagenesis in their model.

Original languageEnglish
Pages (from-to)13-15
Number of pages3
JournalFuture Virology
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2011

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Herpesviridae
Carcinogenesis
Vaccination
Muridae
Viral Genome
Tumor Suppressor Genes
Oncogenes
Neoplasms
Genome
Gene Expression
Cre recombinase

Keywords

  • Cre recombinase
  • herpesvirus
  • hit-and-run scenario
  • mouse model
  • vaccine

ASJC Scopus subject areas

  • Virology

Cite this

Viral hit-and-run tumorigenesis. / Mináróvits, J.; Banati, Ferenc; Niller, Hans Helmut.

In: Future Virology, Vol. 6, No. 1, 01.2011, p. 13-15.

Research output: Contribution to journalArticle

Mináróvits, J, Banati, F & Niller, HH 2011, 'Viral hit-and-run tumorigenesis', Future Virology, vol. 6, no. 1, pp. 13-15. https://doi.org/10.2217/fvl.10.72
Mináróvits, J. ; Banati, Ferenc ; Niller, Hans Helmut. / Viral hit-and-run tumorigenesis. In: Future Virology. 2011 ; Vol. 6, No. 1. pp. 13-15.
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