Violation of distribution symmetry in statistical evaluation of absolute enantioselective synthesis

Béla Barabas, Luciano Caglioti, Claudia Zucchi, Marco Maioli, Emese Gál, Károly Micskei, Gyula Pályi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Enantiomeric excesses obtained in absolute enantioselective synthesis by chiral autocatalysis (Soai-reaction) were statistically analyzed. Two sets of parallel experiments, which were performed under chemically different conditions, are available. One group contains 37, while the other contains 84 preparative results. The former group shows some interesting tendencies but does not give conclusive statistical results. The sample of 84 parallel experiments, providing 39 R- and 45 S-excesses have shown that these data represent two distinct, non-symmetric sets with different non-Gaussian distributions. Clear S preference was found.

Original languageEnglish
Pages (from-to)11506-11510
Number of pages5
JournalJournal of Physical Chemistry B
Volume111
Issue number39
DOIs
Publication statusPublished - Oct 4 2007

    Fingerprint

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this