Világos sejtes focusok humán májrák környezetében. Praeneoplasticus elváltozások, vagy véletlen egybeesés?

A. Zalatnai, Görög Denes

Research output: Contribution to journalArticle

Abstract

Aim of the study: The incidence of preneoplastic liver lesions in human biopsy material was studied retrospectively and a case of a 42-year-old male is described in which clear cell foci and neoplastic nodules were found in the close vicinity of a hepatocellular carcinoma in non-cirrhotic liver. Methods: The authors analyzed the 28-year liver biopsy material diagnosed at the First Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine. Results: Between 1968 and 1997 10 130 liver biopsies have been diagnosed. Out of them there were 5 cases displaying clear cell foci corresponding to the identical lesions regularly found in rodent chemical hepato- carcinogenesis. Hepatocellular carcinoma was associated with these lesions only in 1 case, while in 147 liver cell cancer the "preneoplastic "foci were absent around the tumor. Conclusion: In human liver the clear cell foci/nodules do not seem to represent a preneoplastic condition, and it can be assumed that in the development of human HCCs the focus -→ nodule -→ carcinoma sequence does not play an essential role.

Original languageHungarian
Pages (from-to)74-79
Number of pages6
JournalMagyar Onkologia
Volume43
Issue number1
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Oncology

Cite this

Világos sejtes focusok humán májrák környezetében. Praeneoplasticus elváltozások, vagy véletlen egybeesés? / Zalatnai, A.; Denes, Görög.

In: Magyar Onkologia, Vol. 43, No. 1, 1999, p. 74-79.

Research output: Contribution to journalArticle

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