Vigabatrin pre-treatment prevents hilar somatostatin cell loss and the development of interictal spiking activity following sustained simulation of the perforant path

A. Ylinen, A. Valjakka, H. Lahtinen, R. Miettinen, T. Freund, P. Riekkinen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Somatostatin-containing neurons in the hilus of the dentate gyrus are known to be exceptionally vulnerable in experimental models of epilepsy, as well as in human temporal lobe epilepsy. The position of these cells in the circuitry of the dentate gyrus is ideal for gating the activation evoked by afferents from the entorhinal cortex. In the present study we have shown that the loss of hilar somatostatin-containing neurons, and the development of interictal spiking activity induced by sustained perforant pathway stimulation can be prevented by high doses (500 mg/kg), but not by low doses (100 mg/kg) of vigabatrin, an irreversible inhibitor of GABA-transaminase.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalNeuropeptides
Volume19
Issue number3
DOIs
Publication statusPublished - 1991

Fingerprint

Vigabatrin
Perforant Pathway
Somatostatin-Secreting Cells
Dentate Gyrus
Somatostatin
Neurons
4-Aminobutyrate Transaminase
Entorhinal Cortex
Temporal Lobe Epilepsy
Epilepsy
Theoretical Models
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Vigabatrin pre-treatment prevents hilar somatostatin cell loss and the development of interictal spiking activity following sustained simulation of the perforant path. / Ylinen, A.; Valjakka, A.; Lahtinen, H.; Miettinen, R.; Freund, T.; Riekkinen, P.

In: Neuropeptides, Vol. 19, No. 3, 1991, p. 205-211.

Research output: Contribution to journalArticle

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