Videometric mass flow control: A new method for real-time measurement and feedback control of powder micro-feeding based on image analysis

Lajos Madarász, Ákos Köte, Martin Gyürkés, Attila Farkas, Bence Hambalkó, Hajnalka Pataki, Gergő Fülöp, György Marosi, László Lengyel, Tibor Casian, Kristóf Csorba, Zsombor Kristóf Nagy

Research output: Contribution to journalArticle

Abstract

The present paper reports the first monitoring and control of ultra-low dose powder feeding using a camera image-based mass flow measurement system. Caffeine was fed via a single-screw microfeeder as a model active pharmaceutical ingredient (API). The mass, mass flow and sizes of the particles were successfully monitored in real-time by the developed videometric system consisting of a high-speed process camera coupled with an image analysis software. The system was also tested in feedback control mode to automatically reach the desired mass flow values by adjusting the feeder speed based on the mass flow measured by the image analysis system. Based on these features, the developed videometric system can serve as a multi-purpose PAT-tool and can provide valuable real-time information about the process which is indispensable for modern continuous pharmaceutical manufacturing.

Original languageEnglish
Article number119223
JournalInternational Journal of Pharmaceutics
Volume580
DOIs
Publication statusPublished - Apr 30 2020

Keywords

  • Continuous pharmaceutical manufacturing
  • Dynamic Image Analysis (DIA)
  • Feedback control
  • Machine vision
  • Micro-feeding
  • Process Analytical Technology (PAT)
  • Videometric feeding

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Madarász, L., Köte, Á., Gyürkés, M., Farkas, A., Hambalkó, B., Pataki, H., Fülöp, G., Marosi, G., Lengyel, L., Casian, T., Csorba, K., & Nagy, Z. K. (2020). Videometric mass flow control: A new method for real-time measurement and feedback control of powder micro-feeding based on image analysis. International Journal of Pharmaceutics, 580, [119223]. https://doi.org/10.1016/j.ijpharm.2020.119223