Vessel masking improves densitometric myocardial perfusion assessment.

Tamás Ungi, Zsolt Zimmermann, Erika Balázs, András Lassó, Imre Ungi, T. Forster, András Palkó, Attila Nemes

Research output: Contribution to journalArticle

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Abstract

INTRODUCTION: The objective of treatment in acute myocardial infarction (AMI) is reperfusion of the myocardium at risk. Our goal was to evaluate the effect of vessel masking on videodensitometric assessment of myocardial reperfusion. METHODS: Epicardial vessels were masked out from the densitometric region of interest, where average rise slope (G(max)/T(max)) of time-density curves (TDC) were measured. Measurements were tested to detect indicators of reperfusion as cumulative creatine-kinase (CK) release and ST-resolution by receiver operating characteristic (ROC) curve analysis. RESULTS: When vessel masking was applied before G(max)/T(max) measurement, an improvement has been observed in sensitivity and area under ROC curve to detect indicators of reperfusion as cumulative enzyme release (sensitivity (Se): 85% vs. 61%, area under the curve (AUC): 0.84 vs. 0.76) and ST-resolution (Se: 74% vs. 67%, AUC: 0.83 vs. 0.79). CONCLUSIONS: Selective myocardial perfusion measurement on coronary angiograms is feasible and serves as an informative method to detect myocardial viability after AMI and revascularization therapy. The present study demonstrated that vessel masking improves results compared to simple densitometric analysis.

Original languageEnglish
Pages (from-to)229-236
Number of pages8
JournalInternational Journal of Cardiovascular Imaging
Volume25
Issue number3
Publication statusPublished - Mar 2009

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Reperfusion
Perfusion
ROC Curve
Area Under Curve
Myocardial Infarction
Myocardial Revascularization
Myocardial Reperfusion
Creatine Kinase
Myocardium
Angiography
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ungi, T., Zimmermann, Z., Balázs, E., Lassó, A., Ungi, I., Forster, T., ... Nemes, A. (2009). Vessel masking improves densitometric myocardial perfusion assessment. International Journal of Cardiovascular Imaging, 25(3), 229-236.

Vessel masking improves densitometric myocardial perfusion assessment. / Ungi, Tamás; Zimmermann, Zsolt; Balázs, Erika; Lassó, András; Ungi, Imre; Forster, T.; Palkó, András; Nemes, Attila.

In: International Journal of Cardiovascular Imaging, Vol. 25, No. 3, 03.2009, p. 229-236.

Research output: Contribution to journalArticle

Ungi, T, Zimmermann, Z, Balázs, E, Lassó, A, Ungi, I, Forster, T, Palkó, A & Nemes, A 2009, 'Vessel masking improves densitometric myocardial perfusion assessment.', International Journal of Cardiovascular Imaging, vol. 25, no. 3, pp. 229-236.
Ungi, Tamás ; Zimmermann, Zsolt ; Balázs, Erika ; Lassó, András ; Ungi, Imre ; Forster, T. ; Palkó, András ; Nemes, Attila. / Vessel masking improves densitometric myocardial perfusion assessment. In: International Journal of Cardiovascular Imaging. 2009 ; Vol. 25, No. 3. pp. 229-236.
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AB - INTRODUCTION: The objective of treatment in acute myocardial infarction (AMI) is reperfusion of the myocardium at risk. Our goal was to evaluate the effect of vessel masking on videodensitometric assessment of myocardial reperfusion. METHODS: Epicardial vessels were masked out from the densitometric region of interest, where average rise slope (G(max)/T(max)) of time-density curves (TDC) were measured. Measurements were tested to detect indicators of reperfusion as cumulative creatine-kinase (CK) release and ST-resolution by receiver operating characteristic (ROC) curve analysis. RESULTS: When vessel masking was applied before G(max)/T(max) measurement, an improvement has been observed in sensitivity and area under ROC curve to detect indicators of reperfusion as cumulative enzyme release (sensitivity (Se): 85% vs. 61%, area under the curve (AUC): 0.84 vs. 0.76) and ST-resolution (Se: 74% vs. 67%, AUC: 0.83 vs. 0.79). CONCLUSIONS: Selective myocardial perfusion measurement on coronary angiograms is feasible and serves as an informative method to detect myocardial viability after AMI and revascularization therapy. The present study demonstrated that vessel masking improves results compared to simple densitometric analysis.

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