Abstract
Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.
| Original language | English |
|---|---|
| Article number | e1001450 |
| Journal | PLoS Biology |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2012 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Neuroscience(all)
Cite this
Vesiclepedia : A Compendium for Extracellular Vesicles with Continuous Community Annotation. / Kalra, Hina; Simpson, Richard J.; Ji, Hong; Aikawa, Elena; Altevogt, Peter; Askenase, Philip; Bond, Vincent C.; Borràs, Francesc E.; Breakefield, Xandra; Budnik, Vivian; Búzás, E.; Camussi, Giovanni; Clayton, Aled; Cocucci, Emanuele; Falcon-Perez, Juan M.; Gabrielsson, Susanne; Gho, Yong Song; Gupta, Dwijendra; Harsha, H. C.; Hendrix, An; Hill, Andrew F.; Inal, Jameel M.; Jenster, Guido; Krämer-Albers, Eva Maria; Lim, Sai Kiang; Llorente, Alicia; Lötvall, Jan; Marcilla, Antonio; Mincheva-Nilsson, Lucia; Nazarenko, Irina; Nieuwland, Rienk; Nolte-'t Hoen, Esther N M; Pandey, Akhilesh; Patel, Tushar; Piper, Melissa G.; Pluchino, Stefano; Prasad, T. S Keshava; Rajendran, Lawrence; Raposo, Graca; Record, Michel; Reid, Gavin E.; Sánchez-Madrid, Francisco; Schiffelers, Raymond M.; Siljander, Pia; Stensballe, Allan; Stoorvogel, Willem; Taylor, Douglas; Thery, Clotilde; Valadi, Hadi; van Balkom, Bas W M; Vázquez, Jesús; Vidal, Michel; Wauben, Marca H M; Yáñez-Mó, María; Zoeller, Margot; Mathivanan, Suresh.
In: PLoS Biology, Vol. 10, No. 12, e1001450, 12.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vesiclepedia
T2 - A Compendium for Extracellular Vesicles with Continuous Community Annotation
AU - Kalra, Hina
AU - Simpson, Richard J.
AU - Ji, Hong
AU - Aikawa, Elena
AU - Altevogt, Peter
AU - Askenase, Philip
AU - Bond, Vincent C.
AU - Borràs, Francesc E.
AU - Breakefield, Xandra
AU - Budnik, Vivian
AU - Búzás, E.
AU - Camussi, Giovanni
AU - Clayton, Aled
AU - Cocucci, Emanuele
AU - Falcon-Perez, Juan M.
AU - Gabrielsson, Susanne
AU - Gho, Yong Song
AU - Gupta, Dwijendra
AU - Harsha, H. C.
AU - Hendrix, An
AU - Hill, Andrew F.
AU - Inal, Jameel M.
AU - Jenster, Guido
AU - Krämer-Albers, Eva Maria
AU - Lim, Sai Kiang
AU - Llorente, Alicia
AU - Lötvall, Jan
AU - Marcilla, Antonio
AU - Mincheva-Nilsson, Lucia
AU - Nazarenko, Irina
AU - Nieuwland, Rienk
AU - Nolte-'t Hoen, Esther N M
AU - Pandey, Akhilesh
AU - Patel, Tushar
AU - Piper, Melissa G.
AU - Pluchino, Stefano
AU - Prasad, T. S Keshava
AU - Rajendran, Lawrence
AU - Raposo, Graca
AU - Record, Michel
AU - Reid, Gavin E.
AU - Sánchez-Madrid, Francisco
AU - Schiffelers, Raymond M.
AU - Siljander, Pia
AU - Stensballe, Allan
AU - Stoorvogel, Willem
AU - Taylor, Douglas
AU - Thery, Clotilde
AU - Valadi, Hadi
AU - van Balkom, Bas W M
AU - Vázquez, Jesús
AU - Vidal, Michel
AU - Wauben, Marca H M
AU - Yáñez-Mó, María
AU - Zoeller, Margot
AU - Mathivanan, Suresh
PY - 2012/12
Y1 - 2012/12
N2 - Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.
AB - Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.
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U2 - 10.1371/journal.pbio.1001450
DO - 10.1371/journal.pbio.1001450
M3 - Article
VL - 10
JO - PLoS Biology
JF - PLoS Biology
SN - 1544-9173
IS - 12
M1 - e1001450
ER -