Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Hina Kalra, Richard J. Simpson, Hong Ji, Elena Aikawa, Peter Altevogt, Philip Askenase, Vincent C. Bond, Francesc E. Borràs, Xandra Breakefield, Vivian Budnik, E. Búzás, Giovanni Camussi, Aled Clayton, Emanuele Cocucci, Juan M. Falcon-Perez, Susanne Gabrielsson, Yong Song Gho, Dwijendra Gupta, H. C. Harsha, An HendrixAndrew F. Hill, Jameel M. Inal, Guido Jenster, Eva Maria Krämer-Albers, Sai Kiang Lim, Alicia Llorente, Jan Lötvall, Antonio Marcilla, Lucia Mincheva-Nilsson, Irina Nazarenko, Rienk Nieuwland, Esther N M Nolte-'t Hoen, Akhilesh Pandey, Tushar Patel, Melissa G. Piper, Stefano Pluchino, T. S Keshava Prasad, Lawrence Rajendran, Graca Raposo, Michel Record, Gavin E. Reid, Francisco Sánchez-Madrid, Raymond M. Schiffelers, Pia Siljander, Allan Stensballe, Willem Stoorvogel, Douglas Taylor, Clotilde Thery, Hadi Valadi, Bas W M van Balkom, Jesús Vázquez, Michel Vidal, Marca H M Wauben, María Yáñez-Mó, Margot Zoeller, Suresh Mathivanan

Research output: Contribution to journalArticle

513 Citations (Scopus)

Abstract

Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.

Original languageEnglish
Article numbere1001450
JournalPLoS Biology
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Databases
cell communication
Biomarkers
gold
biomarkers
Vaccines
pathogenesis
Information Dissemination
Genes
researchers
deterioration
RNA
vaccines
Lipids
drugs
Extracellular Vesicles
Communication
lipids
Research Personnel
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., ... Mathivanan, S. (2012). Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation. PLoS Biology, 10(12), [e1001450]. https://doi.org/10.1371/journal.pbio.1001450

Vesiclepedia : A Compendium for Extracellular Vesicles with Continuous Community Annotation. / Kalra, Hina; Simpson, Richard J.; Ji, Hong; Aikawa, Elena; Altevogt, Peter; Askenase, Philip; Bond, Vincent C.; Borràs, Francesc E.; Breakefield, Xandra; Budnik, Vivian; Búzás, E.; Camussi, Giovanni; Clayton, Aled; Cocucci, Emanuele; Falcon-Perez, Juan M.; Gabrielsson, Susanne; Gho, Yong Song; Gupta, Dwijendra; Harsha, H. C.; Hendrix, An; Hill, Andrew F.; Inal, Jameel M.; Jenster, Guido; Krämer-Albers, Eva Maria; Lim, Sai Kiang; Llorente, Alicia; Lötvall, Jan; Marcilla, Antonio; Mincheva-Nilsson, Lucia; Nazarenko, Irina; Nieuwland, Rienk; Nolte-'t Hoen, Esther N M; Pandey, Akhilesh; Patel, Tushar; Piper, Melissa G.; Pluchino, Stefano; Prasad, T. S Keshava; Rajendran, Lawrence; Raposo, Graca; Record, Michel; Reid, Gavin E.; Sánchez-Madrid, Francisco; Schiffelers, Raymond M.; Siljander, Pia; Stensballe, Allan; Stoorvogel, Willem; Taylor, Douglas; Thery, Clotilde; Valadi, Hadi; van Balkom, Bas W M; Vázquez, Jesús; Vidal, Michel; Wauben, Marca H M; Yáñez-Mó, María; Zoeller, Margot; Mathivanan, Suresh.

In: PLoS Biology, Vol. 10, No. 12, e1001450, 12.2012.

Research output: Contribution to journalArticle

Kalra, H, Simpson, RJ, Ji, H, Aikawa, E, Altevogt, P, Askenase, P, Bond, VC, Borràs, FE, Breakefield, X, Budnik, V, Búzás, E, Camussi, G, Clayton, A, Cocucci, E, Falcon-Perez, JM, Gabrielsson, S, Gho, YS, Gupta, D, Harsha, HC, Hendrix, A, Hill, AF, Inal, JM, Jenster, G, Krämer-Albers, EM, Lim, SK, Llorente, A, Lötvall, J, Marcilla, A, Mincheva-Nilsson, L, Nazarenko, I, Nieuwland, R, Nolte-'t Hoen, ENM, Pandey, A, Patel, T, Piper, MG, Pluchino, S, Prasad, TSK, Rajendran, L, Raposo, G, Record, M, Reid, GE, Sánchez-Madrid, F, Schiffelers, RM, Siljander, P, Stensballe, A, Stoorvogel, W, Taylor, D, Thery, C, Valadi, H, van Balkom, BWM, Vázquez, J, Vidal, M, Wauben, MHM, Yáñez-Mó, M, Zoeller, M & Mathivanan, S 2012, 'Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation', PLoS Biology, vol. 10, no. 12, e1001450. https://doi.org/10.1371/journal.pbio.1001450
Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P et al. Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation. PLoS Biology. 2012 Dec;10(12). e1001450. https://doi.org/10.1371/journal.pbio.1001450
Kalra, Hina ; Simpson, Richard J. ; Ji, Hong ; Aikawa, Elena ; Altevogt, Peter ; Askenase, Philip ; Bond, Vincent C. ; Borràs, Francesc E. ; Breakefield, Xandra ; Budnik, Vivian ; Búzás, E. ; Camussi, Giovanni ; Clayton, Aled ; Cocucci, Emanuele ; Falcon-Perez, Juan M. ; Gabrielsson, Susanne ; Gho, Yong Song ; Gupta, Dwijendra ; Harsha, H. C. ; Hendrix, An ; Hill, Andrew F. ; Inal, Jameel M. ; Jenster, Guido ; Krämer-Albers, Eva Maria ; Lim, Sai Kiang ; Llorente, Alicia ; Lötvall, Jan ; Marcilla, Antonio ; Mincheva-Nilsson, Lucia ; Nazarenko, Irina ; Nieuwland, Rienk ; Nolte-'t Hoen, Esther N M ; Pandey, Akhilesh ; Patel, Tushar ; Piper, Melissa G. ; Pluchino, Stefano ; Prasad, T. S Keshava ; Rajendran, Lawrence ; Raposo, Graca ; Record, Michel ; Reid, Gavin E. ; Sánchez-Madrid, Francisco ; Schiffelers, Raymond M. ; Siljander, Pia ; Stensballe, Allan ; Stoorvogel, Willem ; Taylor, Douglas ; Thery, Clotilde ; Valadi, Hadi ; van Balkom, Bas W M ; Vázquez, Jesús ; Vidal, Michel ; Wauben, Marca H M ; Yáñez-Mó, María ; Zoeller, Margot ; Mathivanan, Suresh. / Vesiclepedia : A Compendium for Extracellular Vesicles with Continuous Community Annotation. In: PLoS Biology. 2012 ; Vol. 10, No. 12.
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